{"id":89006,"date":"2018-03-10T00:14:03","date_gmt":"2018-03-10T00:14:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribucion-alelica-de-los-genes-hla-de-clase-ii-en-dos-grupos-etnicos-de-pacientes-brasilenos-con-esclerosis-multiple\/"},"modified":"2018-03-10T00:14:03","modified_gmt":"2018-03-10T00:14:03","slug":"distribucion-alelica-de-los-genes-hla-de-clase-ii-en-dos-grupos-etnicos-de-pacientes-brasilenos-con-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/distribucion-alelica-de-los-genes-hla-de-clase-ii-en-dos-grupos-etnicos-de-pacientes-brasilenos-con-esclerosis-multiple\/","title":{"rendered":"Distribucion alelica, de los genes hla de clase ii en dos grupos etnicos de pacientes brasile\u00f1os con esclerosis multiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> German Navarro Egea <\/strong><\/h2>\n<p>La esclerosis multiple(em) es una enfermedad inflamatoria cronica del sistema nervioso central caracterizada por la destruccion de mielina. Se piensa que la enfermedad puede ser iniciada por factorres ambientales en individuos susceptibles geneticamente. Aunque la mayoria de los estudios de asociacion entre hla y em muestran que la predisposici\u00f3n a la enfermedad se debe principalmente al haplotipo dr2(drbi*1501-dqa1*0102-dqb1*0602) caracteristico de los pacientes de em norterupeos se ha encontrado asociacion con dr en otras poblaciones, lo que revela la existencia de diferencias geneticas entre hla y em en los distintos grupos etnicos estudiados.  en el presente trabajo se ha estudiado por primera vez a dos grupos etnicos conviviendo en un mismo ambiente para intentar esclarecer si este condiciona el patron de asociacion genetica con esta enfermedad. Para ello se procedio a la tipificacion de los alelos hla-drb1 y -dqb1 mediante pcr-ssop y de hla-dqa1 mediante pcr-ssp, de pacientes caucasoides brasile\u00f1os (n=54) y controles (n=92) y de pacientes afrobrasile\u00f1os(n=44) y controles (n=88) de rio de janeiro. Adem\u00e1s se estudiaron determinados aminoacidos codificados por alelos hla-drb1, -dqa1 y -dqb1 observandose las secuencias aminoacidicas de estos (marsch sge, tissue antigens,1998 y zamani ghabanbasani y cols, journal of neuroinmunology, 1995).  en pacientes caucasoides brasile\u00f1os se observa una asociacion con el alelo drb1*1501 para el locus drb1(rr:3.26) y para el locus dqb1 una asociacion con el alelo dqb1*0602(rr:3.44), no apareciendo asociaci\u00f3n con ninguno de los alelos dqa1. El estudio de los haplotipos extendido (rr:3.66) puso de manifiesto la asociaci\u00f3n con el haplotipo drb1*1501,dqa1*0102,dqb1*0602, por lo tanto la asociacion entre hla y em en caucasoides brasile\u00f1os parece ser haplot\u00edpica mas que alelica. En pacientes afrobrasile\u00f1os ninguno de los alelos drb1 se asocio con la enfermedad, siendo el alelo drb1*1503 el m\u00e1s f<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribucion alelica, de los genes hla de clase ii en dos grupos etnicos de pacientes brasile\u00f1os con esclerosis multiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribucion alelica, de los genes hla de clase ii en dos grupos etnicos de pacientes brasile\u00f1os con esclerosis multiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 German Navarro Egea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Alonso Ortiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>Javier Martin iba\u00f1ez (vocal)<\/li>\n<li>oscar Fernandez fernandez (vocal)<\/li>\n<li>Francisco Ruiz-cabello  osuna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de German Navarro Egea La esclerosis multiple(em) es una enfermedad inflamatoria cronica del sistema nervioso central caracterizada por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[114,1738,160,115,35,1737,7834,17],"tags":[2186,4201,185445,45178,2167,44381],"class_list":["post-89006","post","type-post","status-publish","format-standard","hentry","category-acidos-nucleicos","category-antigenos","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-inmunologia","category-malaga","category-quimica","tag-antonio-alonso-ortiz","tag-francisco-ruiz-cabello-osuna","tag-german-navarro-egea","tag-javier-martin-ibanez","tag-miguel-morell-ocana","tag-oscar-fernandez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89006"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89006\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}