{"id":89027,"date":"2018-03-10T00:14:07","date_gmt":"2018-03-10T00:14:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propiedades-inmunoestimuladoras-de-las-protea%c2%adnas-de-choque-termico-hsp70-y-hsp83-de-leishmania-infantum\/"},"modified":"2018-03-10T00:14:07","modified_gmt":"2018-03-10T00:14:07","slug":"propiedades-inmunoestimuladoras-de-las-protea%c2%adnas-de-choque-termico-hsp70-y-hsp83-de-leishmania-infantum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/propiedades-inmunoestimuladoras-de-las-protea%c2%adnas-de-choque-termico-hsp70-y-hsp83-de-leishmania-infantum\/","title":{"rendered":"Propiedades inmunoestimuladoras de las prote\u00ednas de choque t\u00e9rmico hsp70 y hsp83 de leishmania infantum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Rico Errazquin <\/strong><\/h2>\n<p>Las prote\u00ednas de choque t\u00e9rmico o hsp se han descrito como ant\u00edgenos inmunodominantes en multitud de procesos autoinmunes, infecciosos y tumorales. probablemente, la abundancia y conservaci\u00f3n de estas prote\u00ednas contribuyen a que sean unas dianas tan atractivas para el sistema inmune.  desde hace poco m\u00e1s de una d\u00e9cada se est\u00e1 estudiando el potencial de las hsp como mol\u00e9culas inmunoestimuladoras. Concretamente, se ha observado que las hsp de m.Tuberculosis son capaces de estimular la respuesta inmune contra p\u00e9ptidos y prote\u00ednas fusionadas. Conociendo este dato y el papel que tienen la hsp70 y la hsp83 de leishmania infantum como ant\u00edgenos, nos planteamos estudiar la capacidad inmunoestimuladora de estas prote\u00ednas. para ello, dise\u00f1amos pl\u00e1smidos que nos permitieron expresar y purificar en condiciones nativas las prote\u00ednas hsp70 y hsp83 de l.Infantum fusionadas al extremo carboxilo de la prote\u00edna de uni\u00f3n a maltosa mbp de e.Coli, que se utiliz\u00f3 como ant\u00edgeno.  la administraci\u00f3n de este ant\u00edgeno, fusionado al extremo amino de las hsp de l.Infantum, promueve una fuerte respuesta humoral espec\u00edfica contra el ant\u00edgeno inoculado. Adem\u00e1s, comprobamos que es necesario que el ant\u00edgeno est\u00e9 unido f\u00edsicamente a las hsp para que se potencia la respuesta inmune.  la inoculaci\u00f3n de ratones con las prote\u00ednas de fusi\u00f3n mbp-hsp origina una respuesta de anticuerpos relativamente d\u00e9bil y, en ning\u00fan caso, se detectaron anticuerpos anti-hsp autoinmunes.  la administraci\u00f3n de estas prote\u00ednas de fusi\u00f3n es capaz de inducir una respuesta humoral en ratones at\u00edmicos, en los que se detectan niveles significativos de anticuerpos igg e igm espec\u00edficos.  tambi\u00e9n, observamos que las prote\u00ednas hsp70 y hsp83 de l. Infantum son capaces de promover la proliferaci\u00f3n de esplenocitos de ratones sin preinmunizar. la linfoproliferaci\u00f3n depende del estado conformaci\u00f3n de estas prote\u00ednas. mediante estudios de citometr\u00eda de flujo y el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Propiedades inmunoestimuladoras de las prote\u00ednas de choque t\u00e9rmico hsp70 y hsp83 de leishmania infantum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Propiedades inmunoestimuladoras de las prote\u00ednas de choque t\u00e9rmico hsp70 y hsp83 de leishmania infantum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Rico Errazquin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Alonso Debate<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  (secretario) Jimenez ruis <\/li>\n<li>vicente Larraga rodr\u00edguez de vera (vocal)<\/li>\n<li>Manuel Carlos L\u00f3pez l\u00f3pez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Rico Errazquin Las prote\u00ednas de choque t\u00e9rmico o hsp se han descrito como ant\u00edgenos inmunodominantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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