{"id":89040,"date":"2018-03-10T00:14:07","date_gmt":"2018-03-10T00:14:07","guid":{"rendered":""},"modified":"2018-03-10T00:14:07","modified_gmt":"2018-03-10T00:14:07","slug":"efecto-terapeutico-del-gen-hsv-tk-y-ganciclovir-en-el-tratamiento-del-carcinoma-escamoso-bien-diferenciado-de-cabeza-y-cuello-en-un-modelo-animal-inmunodeficiente-y-en-un-modelo-animal-inmunocompetent","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-terapeutico-del-gen-hsv-tk-y-ganciclovir-en-el-tratamiento-del-carcinoma-escamoso-bien-diferenciado-de-cabeza-y-cuello-en-un-modelo-animal-inmunodeficiente-y-en-un-modelo-animal-inmunocompetent\/","title":{"rendered":"Efecto terapeutico del gen hsv-tk y ganciclovir en el tratamiento del carcinoma escamoso bien diferenciado de cabeza y cuello en un modelo animal inmunodeficiente y en un modelo animal inmunocompetente."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Boleas Aguirre M. Soledad <\/strong><\/h2>\n<p>En esta tesis se pretendi\u00f3 estudiar la capacidad de los adenovectores de transducir dos lineas celulares de carcinoma epidermoide. La kb de carcinoma epidermoide bien diferenciado de cavidad oral humano y la sccvii\/sf de carcinoma epidermoide murino. Esto se comprob\u00f3 in vitro e in vivo con la tinci\u00f3n de x-gal despues de exponer las celulas y tumores kb y sccvii\/sf al adenovirus recombinante portador del gen marcador lacz)adcmvlacz).  tambien se quiso estudiar el efecto antitumoral de la transducci\u00f3n del gen suicida de la enzima timidin-kinasa del virus herpes simplex (hvs-tk) asociado a la administraci\u00f3n de ganciclovir (gcv) en las dos lineas celulares anteriormente referidas. La transfecci\u00f3n celular se efectu\u00f3 con el adenovirus recombinante portador del gen de la enzima timidin-kinasa del virus herpes simplex con el promotor del citomegalovirus(adcmvtk).  en el modelo experimental in vitro, en ambas lineas celulares, el efecto antitumoral del tratamiento con el gen terap\u00e9utico (hvs-tk), se valor\u00f3 por la comparaci\u00f3n del porcentaje de supervivencia de las celulas tratadas con el adcmvlacz) y las mismas concentraciones de gcv con respecto a las expuestas al adenovirus marcador (adcmvlacz) y las mismas concentraciones de gcv, que sirven como grupo control. La supervivencia del grupo tratado con adcmvtk\/gcv es inversamente proporcional a la dosis de gcv. Asi mismo se comprob\u00f3 que la supervivencia es menor en las celulas tratadas con adcmvtk\/gcv. asi mismo se comprob\u00f3 que la supervivencia es menor en las c\u00e9lulas tratadas con adcmvtk\/gcv que en las expuesta a adcmvlacz\/gcv, de manera estadisticamente significativa.  en el modelo experimental in vivo, en ambas lineas celulares, se valor\u00f3, mediante la tecnica estereol\u00f3gica de estimaci\u00f3n de volumenes de cavalieri, el porcentaje de volumen de necrosis con respecto al volumen total en todos los tumores, y se compararon los resultados entre el grupo de ratones tratados con adcmvtk y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto terapeutico del gen hsv-tk y ganciclovir en el tratamiento del carcinoma escamoso bien diferenciado de cabeza y cuello en un modelo animal inmunodeficiente y en un modelo animal inmunocompetente.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto terapeutico del gen hsv-tk y ganciclovir en el tratamiento del carcinoma escamoso bien diferenciado de cabeza y cuello en un modelo animal inmunodeficiente y en un modelo animal inmunocompetente. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Boleas Aguirre M. Soledad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Secundino Fern\u00e1ndez Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Bartual pastor <\/li>\n<li>Jorge Roquete gaona (vocal)<\/li>\n<li>pedro Quejada marin (vocal)<\/li>\n<li>Rafael Garcia tapia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Boleas Aguirre M. Soledad En esta tesis se pretendi\u00f3 estudiar la capacidad de los adenovectores de transducir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,155,9,141,1543,17749,347,17],"tags":[185493,91677,1572,185494,17976,17972],"class_list":["post-89040","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-clinicas","category-ciencias-medicas","category-cirugia","category-cirugia-de-garganta-nariz-y-oidos","category-navarra","category-oncologia-clinica","category-quimica","tag-boleas-aguirre-m-soledad","tag-jorge-roquete-gaona","tag-juan-bartual-pastor","tag-pedro-quejada-marin","tag-rafael-garcia-tapia","tag-secundino-fernandez-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89040"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89040\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}