{"id":89073,"date":"2018-03-10T00:14:11","date_gmt":"2018-03-10T00:14:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fisiologico-de-las-isoformas-de-hsos1-en-proliferacion-celular\/"},"modified":"2018-03-10T00:14:11","modified_gmt":"2018-03-10T00:14:11","slug":"estudio-fisiologico-de-las-isoformas-de-hsos1-en-proliferacion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-fisiologico-de-las-isoformas-de-hsos1-en-proliferacion-celular\/","title":{"rendered":"Estudio fisiol\u00f3gico de las isoformas de hsos1 en proliferaci\u00f3n celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natasha Zarich Dimitrevievich <\/strong><\/h2>\n<p>La prote\u00edna hsos1 es un activador de ras que act\u00faa facilitando la transici\u00f3n de ras-gdp a ras-gtp. Se han identificado dos isoformas de hsos1 diferenci\u00e1ndose solamente  por la presencia de un inserto de 15 amino\u00e1cidos localizado en la regi\u00f3n carboxi-terminal de hsos1-isf ii, pr\u00f3ximo a los sitios can\u00f3nicos de uni\u00f3n a grb2, y ausente en hsos1-isf i. Asi mismo, hsos1-isf ii presenta mayor afinidad por la prote\u00edna adaptadora grb2 y mayor actividad biol\u00f3gica respecto a hsos1-isf i. En esta tesis doctoral planteamos identificar la causa de la diferente afinidad de la sisoformas de hsos 1 con grb2 y localizar la zona dentro de la regi\u00f3n carboxi-terminal responsable de la regulaci\u00f3n nefativa de la actividad de hsos1 dilucidando el mecanismo de dicha regulaci\u00f3n. hemos identificado dos nuevos sitios (sh3-mbs) de uni\u00f3n a grb2 en la regi\u00f3n carboxi-terminal de hsos1, estando uno de ellos dentro del inserto de 15 amino\u00e1cidos espec\u00edfico para la isoforma ii y responsable de la mayor afinidad de hsos1-isf ii a grb2 respecto a hsos1-isf i. Tambi\u00e9n demostramos que el nuevo sitio de uni\u00f3n a grb2 (sh3-mbs) presente dentro del inserto es responsable de la diferencia funcional que existe entre las dos isoformas. detectamos que la prote\u00edna hsos1 es capaz in vivo de forma complejos estables con grb2 mediante los nuevos sitios sh3-mbs y que estos complejos se comportan en la activaci\u00f3n de ras y de la ruta de mapk fisiol\u00f3gicamente igual que las prote\u00ednas hsos1 completas. Hemos visto que los mutantes truncados de hsos1 en la regi\u00f3n carboxi-terminal presentan una mayor actividad biol\u00f3gica respecto a las isoformas completas tanto en activaci\u00f3n de ras y la ruta de raf-mek-mapk, como en cooperar con ras en la inducci\u00f3n del fenotipo transformante. Demostramos que la zona responsable de la regulaci\u00f3n negativa dentro de la regi\u00f3n carboxi-terminal de hsos1 es la que incluye los primeros dos sitios de uni\u00f3n a grb2, y que la regi\u00f3n m\u00e1s carboxi-te<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fisiol\u00f3gico de las isoformas de hsos1 en proliferaci\u00f3n celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fisiol\u00f3gico de las isoformas de hsos1 en proliferaci\u00f3n celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natasha Zarich Dimitrevievich <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Rojas Caba\u00f1eros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>margarita Lorenzo balado (vocal)<\/li>\n<li>eugenio Miguel angel Santos de dios (vocal)<\/li>\n<li>almudena Porras gallo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natasha Zarich Dimitrevievich La prote\u00edna hsos1 es un activador de ras que act\u00faa facilitando la transici\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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