{"id":89108,"date":"2001-02-03T00:00:00","date_gmt":"2001-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-l-carnitina-con-cepas-de-escherichia-coli-modelo-no-estructurado-celular-y-enzimatico\/"},"modified":"2001-02-03T00:00:00","modified_gmt":"2001-02-03T00:00:00","slug":"produccion-de-l-carnitina-con-cepas-de-escherichia-coli-modelo-no-estructurado-celular-y-enzimatico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/produccion-de-l-carnitina-con-cepas-de-escherichia-coli-modelo-no-estructurado-celular-y-enzimatico\/","title":{"rendered":"Produccion de  l-(-)-carnitina con cepas de escherichia coli. modelo no estructurado celular y enzim\u00e1tico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Ramon Maiquez Varea <\/strong><\/h2>\n<p>La l(-)-carnitina interviene en el trasnporte de \u00e1cidos grasos de cadena larga a trav\u00e9s de la membrna interna mitocondrial. En la actualidad el 80% de la carnitina utilizada a nivel mundial se obtiene por v\u00eda qu\u00edmica, lo que da lugar a la producci\u00f3n de la mezcla rac\u00e9mica d-lcarnitina. De ah\u00ed que los dep\u00f3sitos existentes de d-carnitina como subproducto sean elevados. este hecho junto a que el proceso de resoluci\u00f3n del racemato supone un problema medioambiental, hace que se incrmente el inter\u00e9s por los m\u00e9todos biol\u00f3gicos de producci\u00f3n.  por otra parte, la purificaci\u00f3ny caracterizaci\u00f3nde enzimas presentes en el metabolismo celular de cepas de escherichia coli como la l(-)-carnitina deshidratasa, crtonobeta\u00edna reductasa y carnitina racemasa por kleber y cols., Permite abordar el desarrollod e procesos de biotransofrmaci\u00f3nde d-carnitina y\/o crotonobeta\u00edna, productos de bajo valor a\u00f1adido, mediante m\u00e9todos biotecnol\u00f3gicos.  el trabajo que se presenta en la presente memoria trata de profundizar en las metodolog\u00edas modelo que establecen las condiciones en las que se desarrollan tanto los procesos que pueden dar lugar a productos asociados al crecimiento celular, como las biotrasformaciones de metabolitos secundarios en ausencia de crecimiento. Tal es el casode la producci\u00f3n de l(-)-carnitina mediante el uso de las cepas de e.Coli 044 k74 y la transformada gen\u00e9ticamente k38pt7-5ke32 en estado durmiente y durante el crecimiento.  adem\u00e1s, el trabajo se ha desarrollado cracterizando la configuraci\u00f3n de un reactor adecuado para realizar el bioproceso y que permita su integraci\u00f3n en la propia l\u00ednea de producci\u00f3n de l(-)-carnitina. Para ello, los estudios realizados contemplan por una parte el an\u00e1lisis de la biotransformaci\u00f3n de crotonobeta\u00edna en l(-)-carnitina enreactores discontinuos, mientras que por otra tambi\u00e9n se han ultimado reactores continuos con suportes d einmovilizaci\u00f3n,. Con tal de obtener l(-)-carnitina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Produccion de  l-(-)-carnitina con cepas de escherichia coli. modelo no estructurado celular y enzim\u00e1tico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Produccion de  l-(-)-carnitina con cepas de escherichia coli. modelo no estructurado celular y enzim\u00e1tico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Ramon Maiquez Varea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Iborra Pastor Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: hasn-peter Kleber <\/li>\n<li>arturo Manjon rubio (vocal)<\/li>\n<li>Manuel Rubio torres (vocal)<\/li>\n<li>n\u00e9stor Torres darias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Ramon Maiquez Varea La l(-)-carnitina interviene en el trasnporte de \u00e1cidos grasos de cadena larga a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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