{"id":89112,"date":"2001-02-03T00:00:00","date_gmt":"2001-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-metodos-modelo-dependiente-y-modelo-independiente-al-analisis-de-la-cinetica-de-distribucion-tisular-de-farmacos\/"},"modified":"2001-02-03T00:00:00","modified_gmt":"2001-02-03T00:00:00","slug":"aplicacion-de-metodos-modelo-dependiente-y-modelo-independiente-al-analisis-de-la-cinetica-de-distribucion-tisular-de-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-de-metodos-modelo-dependiente-y-modelo-independiente-al-analisis-de-la-cinetica-de-distribucion-tisular-de-farmacos\/","title":{"rendered":"Aplicaci\u00f3n de m\u00e9todos modelo-dependiente y modelo-independiente al analisis de la cinetica de distribuci\u00f3n tisular de farmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fraile Lafuente M. Angeles <\/strong><\/h2>\n<p>El objetivo de este trabajo ha sido el estudio comparado de diferentes estrategias modelo-dependiente y modelo-independiente en el an\u00e1lisis farmacocin\u00e9tico de la distribuci\u00f3n tisular. Aplicando diferentes estrategias de an\u00e1lisis compartimental (modelo tricompartimental mamilar y modelo basado en la consideraci\u00f3n de los tejidos de inter\u00e9s como subcompartimentos anat\u00f3micos) a datos simulados de niveles de amicacina en plasma, compartimento perif\u00e9rico acesible y profundo, sin o con error aleatorio, se ha comprobado que  el modelo mamilar resulta m\u00e1s adecuado para la estimaci\u00f3n de los par\u00e1metros de distribuci\u00f3n, especialmente cuando existe un error residual significativo.  se ha demostrado la validez de m\u00e9todos estad\u00edsticos de dise\u00f1o de experimentos en la optimizaci\u00f3n de par\u00e1metros farmacocin\u00e9ticos de distribuci\u00f3n tisular. la comparaci\u00f3n de diferentes estrategias de deconvoluci\u00f3n num\u00e9rica (directa, anal\u00edtica e indirecta por aproximaci\u00f3n semiparam\u00e9trica y convoluci\u00f3n combianda con regresi\u00f3n no lineal) utilizando datos simulados de niveles de amicacina y datos reales de concentraci\u00f3n de netilmicina en plasma y tejido demuestra que, manejando datos cone rror significativo, la deconvoluci\u00f3n anal\u00edtica y sobre todo la deconvoluci\u00f3n con aproximaci\u00f3n smiparam\u00e9trica resultan m\u00e1s eficaces que la deconvoluci\u00f3n num\u00e9rica. La deconvoluci\u00f3n con aproximaci\u00f3n semiparam\u00e9trica permite calcular el aclaramiento de distribuci\u00f3n y el coeficiente de reparto. En tejidos fuertemente irrigados con distribuci\u00f3n limitada por el flujo, se calculan tiempos medios de tr\u00e1nsito incoherentes por diferencia entre el tiempo medio de residencia en tejido y el tiempo medio de residencia en plasma. El m\u00e9todo de deconvoluci\u00f3n con aproximaci\u00f3n semiparam\u00e9trica resulta asimismo superior para el c\u00e1lculo del tmt. La funci\u00f3n gamma constituye una buena alternativa a las funciones exponenciales para el ajuste de niveles plasm\u00e1ticos de f\u00e1rmacos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de m\u00e9todos modelo-dependiente y modelo-independiente al analisis de la cinetica de distribuci\u00f3n tisular de farmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de m\u00e9todos modelo-dependiente y modelo-independiente al analisis de la cinetica de distribuci\u00f3n tisular de farmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fraile Lafuente M. Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Martinez Lanao<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Domenech berrozpe <\/li>\n<li>amparo S\u00e1nchez navarro (vocal)<\/li>\n<li>gloria Frutos cabanillas (vocal)<\/li>\n<li>guillermo S\u00e1nchez leon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fraile Lafuente M. Angeles El objetivo de este trabajo ha sido el estudio comparado de diferentes estrategias [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,483,17648,9386],"tags":[9483,185599,64169,185600,13795,9410],"class_list":["post-89112","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-procesos-metabolicos-de-los-farmacos","category-salamanca","tag-amparo-sanchez-navarro","tag-fraile-lafuente-m-angeles","tag-gloria-frutos-cabanillas","tag-guillermo-sanchez-leon","tag-jose-domenech-berrozpe","tag-jose-Martinez-lanao"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89112"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89112\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}