{"id":89115,"date":"2001-02-03T00:00:00","date_gmt":"2001-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-clinicopatologica-e-inmunohistoqua%c2%admica-del-cancer-de-mama-familiar\/"},"modified":"2001-02-03T00:00:00","modified_gmt":"2001-02-03T00:00:00","slug":"caracterizacion-clinicopatologica-e-inmunohistoqua%c2%admica-del-cancer-de-mama-familiar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-clinicopatologica-e-inmunohistoqua%c2%admica-del-cancer-de-mama-familiar\/","title":{"rendered":"Caracterizacion clinicopatol\u00f3gica e inmunohistoqu\u00edmica del c\u00e1ncer de mama familiar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Perez Valles <\/strong><\/h2>\n<p>Con el objeto de profundizar en el conocimiento del c\u00e1ncer de mama familiar y en su diferenciaci\u00f3nd el c\u00e1ncer de mama espor\u00e1dico, as\u00ed como para valorar la eficacia de los anticuerpos comerciales anti prote\u00edna brca1, se realiz\u00f3 el sigueinte trabajo que consta de dos partes. Por un lado el estudio de la presencia de mutaciones geminales del gen brca1 en muestras de sangre de pacientes con c\u00e1ncer de mama familiar y espor\u00e1dico. Por otro lado es estudio histol\u00f3gico e inmunohistoqu\u00edmico en muestras enparafina de tumores de pacientes con c\u00e1ncer de mama familiar y espor\u00e1dico. Adem\u00e1s, se recogieron datos cl\u00ednicos de todas las pacientes.  para el estudio de mutaciones se utilizaron las t\u00e9cnicas de \u00abprotein truncation test\u00bb (ptt) y \u00abconformational sensitive gl electrophoresis\u00bb (cgse) seguidas de secuenciaci\u00f3n. Para el estudio inmunohistoqu\u00edmico se usaron anticuerpos anti-porte\u00edna brca1 (d-20, i-20, k-18 y ms110) y anticuerpos contra receptor de estr\u00f3geno re, receptor de progesterona rp, p-53, c-erbb-2, catepsina-d y bcl-2.  se encontraron un total de ocho mutaciones germinales diferentes del gen brca1, tres de ellas produc\u00edan prote\u00ednas truncadas. Histol\u00f3gicamente los tumores del grupod e pacientes conc\u00e1ncer de mama familiar asociado a brca1 fuer\u00f3n m\u00e1s grecuentemente carcinomas medulares de alto grado histol\u00f3gico, y cl\u00ednicamente estas mujeres presentaronm\u00e1s baja edad al diagn\u00f3stico que el resto.  se encontr\u00f3 una tinci\u00f3n heterog\u00e9nea con los anticuerpos anti brca1, sind iferencias entre casos familiares y casos espor\u00e1dicos y tambpoco entre casos con y sin mutaciones. La tinci\u00f3n para re, rp y bcl-2 result\u00f3 m\u00e1s grecuentemente negativa enlos tumores de pacientes con c\u00e1ncer familiar asociado a brca1 y estos tumores resultaron tambi\u00e9n m\u00e1s frecuentemente p53 positivos. La tinci\u00f3n para c-erbb-2 y catepsina-d no mostr\u00f3 diferencias entre casos familiares y espor\u00e1dicos.  de lo anterior se concluye que ninguno de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion clinicopatol\u00f3gica e inmunohistoqu\u00edmica del c\u00e1ncer de mama familiar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion clinicopatol\u00f3gica e inmunohistoqu\u00edmica del c\u00e1ncer de mama familiar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Perez Valles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Mariorell Cebollada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Trullenque peris <\/li>\n<li>Francisco Martinez diaz (vocal)<\/li>\n<li>Carlos V\u00e1zquez albadalejo (vocal)<\/li>\n<li>Francisco Javier S\u00e1ez castresana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Perez Valles Con el objeto de profundizar en el conocimiento del c\u00e1ncer de mama familiar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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