{"id":89165,"date":"2001-06-03T00:00:00","date_gmt":"2001-06-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-la-expresion-de-quimioquinas-en-fibroblastos-dermicos-en-la-esclerosis-sistematica\/"},"modified":"2001-06-03T00:00:00","modified_gmt":"2001-06-03T00:00:00","slug":"estudio-de-la-regulacion-de-la-expresion-de-quimioquinas-en-fibroblastos-dermicos-en-la-esclerosis-sistematica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-regulacion-de-la-expresion-de-quimioquinas-en-fibroblastos-dermicos-en-la-esclerosis-sistematica\/","title":{"rendered":"Estudio de la regulacion de la expresion de quimioquinas en fibroblastos dermicos en la esclerosis sistematica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Galindo Izquierdo <\/strong><\/h2>\n<p>En este estudio se analizan las diferencias en el patron de expresion basal de quimioquinas entre fibroblastos dermicos sanos y de pacientes con esclerosis sistematica, asi como en la respuesta a los estimulos redox y en su regulacion. Los resultados que se presentan demuestran que los fibroblastos dermicos son capaces de expresar constitutivamente mcp-1 e il-8, y que la sintesis de estas quimioquinas aumenta tras la exposicion a hipoxia\/reoxigenacion. A diferencia de los sanos, aquellos que proceden de piel esclerodermica presentan una expresion constitutiva de mcp-1 aumentada, que no se modifica tras la exposici\u00f3n al estr\u00e9s oxidativo y, que no parece dependente de la activacion de nf-kb y ap-1, en ambos tipos de fibroblastos se ha demostrado que la proteina mcp-1 secretada es quimiotactica para celulas mononucleares y, de manera muy heterogenea, parece estar implicada en la expresi\u00f3n de procolageno alfa-1. Estos resultados se han confirmado in vivo por inmunohistoquimica, ya que solo se ha observado expresion de mcp-1 en las muestras de piel esclerodermica. La expresi\u00f3n de mcp-1 en estas muestras se extiende a los queratinocitos de las capas profundas de la epidermis y a las celulas mononucleares ademas de a los fibroblastos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la regulacion de la expresion de quimioquinas en fibroblastos dermicos en la esclerosis sistematica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la regulacion de la expresion de quimioquinas en fibroblastos dermicos en la esclerosis sistematica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Galindo Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pablos Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Solis  herruzo <\/li>\n<li>armando Laffou roca (vocal)<\/li>\n<li>Jes\u00fas Egido de los rios (vocal)<\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Galindo Izquierdo En este estudio se analizan las diferencias en el patron de expresion basal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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