{"id":89192,"date":"2001-08-03T00:00:00","date_gmt":"2001-08-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-enantioselectiva-de-aminoacidos-de-interes-farmacologico-y-de-nuevos-derivados-quirales-del-ferroceno\/"},"modified":"2001-08-03T00:00:00","modified_gmt":"2001-08-03T00:00:00","slug":"sintesis-enantioselectiva-de-aminoacidos-de-interes-farmacologico-y-de-nuevos-derivados-quirales-del-ferroceno","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-enantioselectiva-de-aminoacidos-de-interes-farmacologico-y-de-nuevos-derivados-quirales-del-ferroceno\/","title":{"rendered":"Sintesis enantioselectiva de aminoacidos de interes farmacologico y de nuevos derivados quirales del ferroceno."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Catasus Asenjo <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha realizado por primera vez la sintesis enantioselectiva de la n-boc-d-allo-isoleucina utilizando la epoxidacion asimetrica de sharpless como paso sintetico clave.  tambien se ha realizado por primera vez la sintesis del acido (3r,4s)-4-(n-metilamino)-3-hidroxi-5-fenilpentanoico(constituyente de la hapalosina) en forma protegida, a partir de sustancias aquirales. por otro lado se ha comprobado que la reacci\u00f3n de aminohidroxilaci\u00f3n catalitica asim\u00e9trica de sharpless no es generalizable para cualquier olefina. Concretamente es sensible a la presencia de un sustituyente alquilo voluminoso en el carbono en x a la olefina. Asi como la aplicaci\u00f3n de la reaccion de aminohidroxilacion no nos ha permitido la obtencion de x-aminoaldehidos i x-aminoesteres a partir de eteres probablemente, a las condiciones de reaccion.  se han desenvolupado nuevas metodolog\u00edas de sintesis enantioselectiva de compuestos ferrocenicos con quiralidad central: preparacion del 3-amino-3-ferrocenil-1,2-pronodiol en sus dos formas enantiomericas; sintesis del (2s,3s)-3-amino-3-ferrocenil-2-hidroxipropanoato de etilo el cual supone un ejemplo de incorporacion de un nucleo ferrocenico en el esqueleto carbonado de un aminoacido, obtencion de la 2,2-dicloro-3-ferrocenilaziridina(primer ejemplo de esta familia de compuestos), sintesis y caracterizacion de un x-ferrocenil oxirano: el trans-2-fenil-3-ferroceniloxirano, cuya posterior obertura con variedad de nucleofilos nos puede concluir a nuevos compuestos ferrocenicos con potencial interes como ligandos o auxiliares utiles en catalisis asimetrica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis enantioselectiva de aminoacidos de interes farmacologico y de nuevos derivados quirales del ferroceno.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis enantioselectiva de aminoacidos de interes farmacologico y de nuevos derivados quirales del ferroceno. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Catasus Asenjo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Moyano Baldoire<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Peric\u00ed\u00a0s brondo <\/li>\n<li>rosa Mar\u00eda Ortu\u00f1o mingarro (vocal)<\/li>\n<li>carmen Almansa rosales (vocal)<\/li>\n<li>angel Guerrero perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Catasus Asenjo En la presente tesis doctoral se ha realizado por primera vez la sintesis enantioselectiva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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