{"id":89260,"date":"2001-12-03T00:00:00","date_gmt":"2001-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-serina-treonina-protea%c2%adnfosfatasas-en-la-analgesia-inducida-por-agonistas-de-receptores-opioidesmu-y-de-otros-receptores-acoplados-a-las-protea%c2%adnas-g-i-o\/"},"modified":"2001-12-03T00:00:00","modified_gmt":"2001-12-03T00:00:00","slug":"papel-de-las-serina-treonina-protea%c2%adnfosfatasas-en-la-analgesia-inducida-por-agonistas-de-receptores-opioidesmu-y-de-otros-receptores-acoplados-a-las-protea%c2%adnas-g-i-o","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-las-serina-treonina-protea%c2%adnfosfatasas-en-la-analgesia-inducida-por-agonistas-de-receptores-opioidesmu-y-de-otros-receptores-acoplados-a-las-protea%c2%adnas-g-i-o\/","title":{"rendered":"Papel de las serina\/treonina prote\u00ednfosfatasas en la analgesia inducida por agonistas de receptores opioidesmu y de otros receptores acoplados a las prote\u00ednas g i\/o"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Moncada Iba\u00f1ez Ana M. <\/strong><\/h2>\n<p>En este trabajo experimental evaluamos el efecto de dos inhibidores de las serina\/treonina prote\u00ednfosfatasas, el \u00e1cido okadaico y la cantaridiana, y de un an\u00e1logo inactivo del \u00e1cido okadaico, la norokadaona, en la actividad analg\u00e9sica de diferentes f\u00e1rmacos que tienen en com\u00fan el que act\u00faan a trav\u00e9s de receptores acoplados a prote\u00ednas g i\/o dichos f\u00e1rmacos son agonistas de receptores opioides u (morfina, buprenorfina, fentanilo, metadona y levorfanol), k(u-50,488h), de receptores adren\u00e9rgicos a2(clonidina) y de receptores gaba b(baclofeno).  en primer lugar comprobamos que, tal y como era de esperar, todos los agonistas de receptores acoplados a las prote\u00ednas gi\/o utilizados, administratos pro v\u00eda subcut\u00e1nea, produc\u00edan analgesia cuando sus efectos se evaluaban a lo largo del tiempo en el test de retirada de la cola de un foco calor\u00edfico en ratones.  en segundo lugar, se pudo comprobar que los efectos analg\u00e9sicos de los agonistas de receptores opioides u morfina, buprenorfina y metadona; del agonista de receptores adren\u00e9rgicos a2 clonidina y del gaba b baclofeno, revert\u00edan de una manera dosis-dependiente, con la administraci\u00f3n intracerebroventricular de los inhibidores de las fosfatas, el \u00e1cido okadaico y la cantaridina; el orden de potencia de estas dos sustancias para inhibir los efectos antinociceptivos in vivo concuerdan con los datos de inhibici\u00f3n de estas enzimas \u00abin vitro\u00bb descritos en la literatura. Sin embargo, la 1-norokadaona, un an\u00e1logo del \u00e1cido okadaico desprovisto de capacidad para inhibir las fosfatasas no modific\u00f3 la actividad antinociceptiva de ninguno de los agonistas de receptores acoplados a prote\u00ednas gi\/o estudiados, aunque se utiliz\u00f3 en un rango de dosis suficientemente amplio.  por \u00faltimo, el efecto que produjeron los inhibidores de las enzimas serina\/treonina prote\u00ednfosfatasas fue diferencial, dado que inhibieron los efectos de los agonistas de receptores acoplados a las prote\u00edna<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las serina\/treonina prote\u00ednfosfatasas en la analgesia inducida por agonistas de receptores opioidesmu y de otros receptores acoplados a las prote\u00ednas g i\/o<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las serina\/treonina prote\u00ednfosfatasas en la analgesia inducida por agonistas de receptores opioidesmu y de otros receptores acoplados a las prote\u00ednas g i\/o <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Moncada Iba\u00f1ez Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esperanza Del Pozo Gavil\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  amor Hurle  gonzalez <\/li>\n<li>Elena Su\u00e1rez gonz\u00e1lez (vocal)<\/li>\n<li>pilar S\u00e1nchez blazquez (vocal)<\/li>\n<li>M\u00aa concepci\u00f3n Iribar ibabe (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Moncada Iba\u00f1ez Ana M. En este trabajo experimental evaluamos el efecto de dos inhibidores de las serina\/treonina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,189,957,4275],"tags":[9353,65553,9874,185826,28458,7569],"class_list":["post-89260","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-neurociencias","tag-elena-suarez-gonzalez","tag-esperanza-del-pozo-gavilan","tag-maria-amor-hurle-gonzalez","tag-moncada-ibanez-ana-m","tag-ma-concepcion-iribar-ibabe","tag-pilar-sanchez-blazquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89260"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89260\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}