{"id":89309,"date":"2018-03-10T00:14:28","date_gmt":"2018-03-10T00:14:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-la-desoxivariolina-b-y-analogos-de-5-pirimidilpirido-3a245-pirrolo-12-c-pirimidinas\/"},"modified":"2018-03-10T00:14:28","modified_gmt":"2018-03-10T00:14:28","slug":"sintesis-de-la-desoxivariolina-b-y-analogos-de-5-pirimidilpirido-3a245-pirrolo-12-c-pirimidinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-la-desoxivariolina-b-y-analogos-de-5-pirimidilpirido-3a245-pirrolo-12-c-pirimidinas\/","title":{"rendered":"Sintesis de la desoxivariolina b y analogos de 5-pirimidilpirido [3\u00c2\u00bf,2:4,5] pirrolo [1,2-c] pirimidinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Fernandez Bleda <\/strong><\/h2>\n<p>Los objetivos de la presente tesis doctoral se han enmarcado en desarrollar una s\u00edntesis vers\u00e1til de la variolina b, alcaloide de origen marino que fue aislado en 1994 de la esponja del ant\u00e1rtico kirkpatrickia varialosa, y el cual ha presentado una potente actividad antitumoral y antiv\u00edrica, que permitiera no n\u00f3lo alcanzar el producto natural sino tambien an\u00e1logos funcionales con el fin de obtener compuestos con actividad biol\u00f3gica potenciada.  as\u00ed mismo se plante\u00f3 desarrollar metodolog\u00edas de s\u00edntesis de an\u00e1logos estructuralmente simplificados para ensayar su actividad biol\u00f3gica.  los resultados obtenidos han permitido poner a punto una metodolog\u00eda para preparaci\u00f3n de sistemas tric\u00edclicos in\u00e9ditos en la literatura como 3-aril y 3-heteroaril-7-azaindoles a trav\u00e9s de una reacci\u00f3n de acoplamiento catalizada por paladio entre un organoestannano y un derivado halogenado, como an\u00e1logos simplificados de la variolina b.  tambi\u00e9n se ha desarrollado una s\u00edntesis del n\u00facleo bic\u00edclico de 1,2-dihidropirrolo[1,2-c]pirimidin-1-ona, habi\u00e9ndose establecido metodolog\u00edas para su funcionalizaci\u00f3n en las posiciones 5 y\/o 7, metodolog\u00edas que han permitido preparar sistemas m\u00e1s complejos de 5-heteroarilpirrolopirimidonas, como an\u00e1logos estructuralmente simplificados de la variolina b.  a partir de un 7-azaindol se ha desarrollado la primera s\u00edntesis total del nucleo de 9-amino-5-aminopirimidilpirido [3\u00c2\u00bf.2\u00c2\u00bf:4,5]pirrolo [1,2-c]pirimidina, nucleo estructural de la variolina b, y se han preparado diversos an\u00e1logos funcionales del alcaloide, as\u00ed como un precursor inmediato de su s\u00edntesis.  la inactividad farmacol\u00f3gica de los an\u00e1logos simplificados han demostrado la importancia del sistema tetrac\u00edclico para la actividad del alcaloide.  los an\u00e1logos funcionales preparados han resultado muy activos frente a carcinomas humanos, habi\u00e9ndose obtenido incluso compuestos con una mayor actividad y selectividad que el producto natural<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de la desoxivariolina b y analogos de 5-pirimidilpirido [3\u00c2\u00bf,2:4,5] pirrolo [1,2-c] pirimidinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de la desoxivariolina b y analogos de 5-pirimidilpirido [3\u00c2\u00bf,2:4,5] pirrolo [1,2-c] pirimidinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Fernandez Bleda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Alvarez Domingo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Albericio palomera <\/li>\n<li>julio \u00e1lvarez-builla g\u00f3mez (vocal)<\/li>\n<li>jan Bergman (vocal)<\/li>\n<li> Fuente blanco Jos\u00e9 a. de la (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Fernandez Bleda Los objetivos de la presente tesis doctoral se han enmarcado en desarrollar una s\u00edntesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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