{"id":89333,"date":"2018-03-10T00:14:28","date_gmt":"2018-03-10T00:14:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-gen-acii-activador-de-clase-ii\/"},"modified":"2018-03-10T00:14:28","modified_gmt":"2018-03-10T00:14:28","slug":"caracterizacion-del-gen-acii-activador-de-clase-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-del-gen-acii-activador-de-clase-ii\/","title":{"rendered":"Caracterizaci\u00f3n del gen acii\/activador de clase ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Vanina Forcales Fernandez <\/strong><\/h2>\n<p>Se ha caracterizado un nuevo factor de transcripci\u00f3n denominado acii, implicado en la regulaci\u00f3n de la expresi\u00f3n de los genes de clase ii del complejo principal de histocompatibilidad. Las mol\u00e9culas de clase ii tienen una funci\u00f3n clave en la respuesta inmunitaria. Su expresi\u00f3n es miu especif\u00edca y se encuentra regulada mayoritariamente a nivel de la transcripci\u00f3n. El factor acii tambi\u00e9n tiene una expresi\u00f3n espec\u00edfica de tejido e id\u00e9ntica a la de los genes de clase ii. Su patr\u00f3n de expresi\u00f3n es temprano expres\u00e1ndose previamente a los genes de clase ii y sin requerir de la s\u00edntesis proteica de novo tras una inducci\u00f3n mediada por el ifny.  la inducci\u00f3n mediada por el ifny se produce a trav\u00e9s de la via jak\/stat, as\u00ed el homod\u00edmero activo de stat se une a las cajas gas presentes en el promotor de acii, induciendo su expresi\u00f3n. La expresi\u00f3n constitutiva en los linfocitos b est\u00e1 mediada por el factor lyf1, espec\u00edfico del linaje linfoc\u00edtico. El promotor de acii no contiene caja tata aunque posee  una caja unificadora y varias cajas sp1 y usf definidas como iniciadoras de la transcripci\u00f3n en muchos genes tata-less. Adem\u00e1s posee varios inicios de transcripci\u00f3n sugiriendo la presencia de m\u00e1s de un promotor que regule la expresi\u00f3n de acii en distintos tipos celulares de forma distinta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del gen acii\/activador de clase ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del gen acii\/activador de clase ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Vanina Forcales Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Celada Cotarelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge  (secretario) Lloberas cavero <\/li>\n<li> Castrillo diez Jos\u00e9 Luis (vocal)<\/li>\n<li>purificacion Mu\u00f1oz canoves (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Vanina Forcales Fernandez Se ha caracterizado un nuevo factor de transcripci\u00f3n denominado acii, implicado en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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