{"id":89344,"date":"2018-03-10T00:14:28","date_gmt":"2018-03-10T00:14:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/derivados-de-dioxidos-de-benzotiadiazina-btd-como-potentes-inhibidores-no-nucleosidicos-de-citomegal-o-virus-humano\/"},"modified":"2018-03-10T00:14:28","modified_gmt":"2018-03-10T00:14:28","slug":"derivados-de-dioxidos-de-benzotiadiazina-btd-como-potentes-inhibidores-no-nucleosidicos-de-citomegal-o-virus-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/derivados-de-dioxidos-de-benzotiadiazina-btd-como-potentes-inhibidores-no-nucleosidicos-de-citomegal-o-virus-humano\/","title":{"rendered":"Derivados de dioxidos de benzotiadiazina (btd) como potentes inhibidores no-nucleosidicos de citomegal o virus humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Gil Ayuso Gontan <\/strong><\/h2>\n<p>Citomegalovirus humano (hcmv), es un virus altamente espec\u00edfico, que presenta una elevada morbi, mortalidad entre la poblaci\u00f3n inmunodeprimida, especialmente entre los receptores de transplante de \u00f3rganos y los pacientes con sida. Hay por tanto una necesidad urgente de encontrar nuevos f\u00e1rmacos activos frente a hcmv, menos t\u00f3xicos, con una biodisponibilidad, y que adem\u00e1s act\u00faen por mecanismos de acci\u00f3n diferentes a los ya existentes. en esta memoria, se ha sintetizado la segunda generaci\u00f3n de derivados de di\u00f3xidos de 2,1,3-benzotiadiazina (btd): los derivados de dibencil btd, que han demostrado ser potentes inhibidores no-nucleos\u00eddicos de hcmv, con una ci50 entre 3-10 um. Algunos de los compuestos preparados, mostraron tambi\u00e9n actividad frente al virus de la inmunodeficiencia humana tipos 1 y 2, y frente a cepas salvajes de hcmv aisladas de pacientes humanos, manteniendo tambi\u00e9n su actividad frente a una cepa de hcmv resistente a ganciclovir.  la metodolog\u00eda comfa (comparative molecualr field analysis), ha sido empelada para general un modelo, bas\u00e1ndose en 32 derivados de btd previamente sintetizados y evaluados, que ha permitido delinear los requisitos estructurales y electr\u00f3nicos necesarios para aumentar la actividad anti-hcmv. El modelo comfa, has sido empleado para dise\u00f1ar dos nuevas familias de btd. La s\u00edntesis y evaluaci\u00f3n antiviral de estos nuevos derivados, ha permitido aumentar la actividad anti-hcmv de estos nuevos inhibidores. se han llevado a cabo estudios farmacol\u00f3gicos iniciales, destinados a la determinaci\u00f3n del mecanismo de acci\u00f3n de los derivados de btd, as\u00ed como estudios farmacocin\u00e9ticos preliminares. por tanto, los derivados de clorofenilmetil btd, pueden considerarse compotentes inhibidores no-nucleos\u00eddicos de hcmv, que act\u00faan por un mecanismo de acci\u00f3n diferente a los f\u00e1rmacos actualmente comercializados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Derivados de dioxidos de benzotiadiazina (btd) como potentes inhibidores no-nucleosidicos de citomegal o virus humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Derivados de dioxidos de benzotiadiazina (btd) como potentes inhibidores no-nucleosidicos de citomegal o virus humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Gil Ayuso Gontan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Martinez Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda del carmen Avenda\u00f1o l\u00f3pez <\/li>\n<li>Francisco Palacios gambra (vocal)<\/li>\n<li>Jos\u00e9 Elguero bertolini (vocal)<\/li>\n<li>pilar Goya laza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Gil Ayuso Gontan Citomegalovirus humano (hcmv), es un virus altamente espec\u00edfico, que presenta una elevada morbi, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,457,416],"tags":[59469,139278,33655,5627,17715,7320],"class_list":["post-89344","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-farmaceutica","category-quimica-organica","tag-ana-Martinez-gil","tag-carmen-gil-ayuso-gontan","tag-francisco-palacios-gambra","tag-jose-elguero-bertolini","tag-maria-del-carmen-avendano-lopez","tag-pilar-goya-laza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89344"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89344\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}