{"id":89349,"date":"2018-03-10T00:14:28","date_gmt":"2018-03-10T00:14:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-del-dna-en-el-alcoholismo\/"},"modified":"2018-03-10T00:14:28","modified_gmt":"2018-03-10T00:14:28","slug":"polimorfismos-del-dna-en-el-alcoholismo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-del-dna-en-el-alcoholismo\/","title":{"rendered":"Polimorfismos del dna en el alcoholismo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Julia Pastor Encinas <\/strong><\/h2>\n<p>Hemos estudiado mediante reacci\u00f3n en cadena de la polimerasa pcr y posterior digesti\u00f3n con enzimas de restricci\u00f3n polimorfismos de genes:  1,- implicados en la dependencia del alcohol (receptor opioide, 4 y receptor de serotonina).  2,- relacionados con el metabolismo del etanol y de otros t\u00f3xicos (cyp2e2, cyp2d6 y gstm1).  3,- que codifican citocinas que intervienen en la patogenia de la eha (il-1rn, i1 + 1beta y tnf-l).  demostramos  1,- una asociaci\u00f3n entre las variantes al\u00e9licas del receptor de la serotonina y la eha de manera que los individuos homocigotos para el alelo c1 de este gen tienen una menos incidencia de eha.  2,- no hemos econtrado ninguna asociaci\u00f3n significativa entre alcoholismo o eah y las variantes al\u00e9licas de los genes receptor opioide, cyp2e1, cyp2d6 y gstm1.  3,- el haplotipo formado por el alelo a1 del gen il-1rn y el alelo a1 del polimorfismo enposici\u00f3n -511 el gen il-1beta se asocia con una mayor susceptibilidad para desarrollar alcoholismo y no se asocia con la eha. este hecho sugiere que dichos genes est\u00e1n implicados enprocesos cerebrales relacionados con el desarrollo del h\u00e1bito alcoh\u00f3lico, o bien que existe otro gen en su proximidad, y desconocido hasta el momento, implicado en este fen\u00f3meno.  4,- de entre los individuos alcoh\u00f3licos s\u00f3lo los portadores homocigotos del polimorfismo en posici\u00f3n +3953 del gen il-1beta presentan una mayor predisposici\u00f3n para desarrollar dependencia del alcohol.  5,- los portadores del alelo a del polimorfismo en posici\u00f3n -238 del gen tnf &#8211; desarrollan eha con mayor frecuencia que los no portadores lo que sugiere que la variante proteica codificada por este alelo puede ejercer un efecto nocivo sobre el hepatocito en el alcoholismo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos del dna en el alcoholismo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos del dna en el alcoholismo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Julia Pastor Encinas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Laso Guzman<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li> \u00e1lvarez gonz\u00e1lez Francisco Javier (vocal)<\/li>\n<li>lu\u00eds Gonz\u00e1lez villar\u00f3n (vocal)<\/li>\n<li> Avial escribano Jos\u00e9 Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Julia Pastor Encinas Hemos estudiado mediante reacci\u00f3n en cadena de la polimerasa pcr y posterior digesti\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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