{"id":89350,"date":"2018-03-10T00:14:28","date_gmt":"2018-03-10T00:14:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-cerebro-auditivo-del-hamster-dorado-mesocricetus-auratus-normal-y-de-la-linea-gpg-vall\/"},"modified":"2018-03-10T00:14:28","modified_gmt":"2018-03-10T00:14:28","slug":"estudio-del-cerebro-auditivo-del-hamster-dorado-mesocricetus-auratus-normal-y-de-la-linea-gpg-vall","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-del-cerebro-auditivo-del-hamster-dorado-mesocricetus-auratus-normal-y-de-la-linea-gpg-vall\/","title":{"rendered":"Estudio del cerebro auditivo del hamster dorado \u00abmesocricetus auratus\u00bb normal y de la linea gpg\/vall"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ver\u00f3nica Fuentes Santamar\u00eda <\/strong><\/h2>\n<p>La l\u00ednea de h\u00e1msters gpg\/vall empleada en el desarrollo de este trabajo presenta crisis convulsivas audi\u00f3genas de origen gen\u00e9tico. Esta crisis se desencadena con est\u00edmulos de 1-20 khz de frecuencia y 60-80 db de intensidad. al ser un sonido el desencadenante de la crisi, la susceptibilidad a padecer estos episodios puede ser el resultado de una serie de alteraciones en el sistema auditivo de estos animales. Realizamos un an\u00e1lisis de los n\u00facleos auditivos del h\u00e1mster gpg\/vall y del h\u00e1mster control para encontrar diferencias que pudieran explicar la g\u00e9nesis de esta crisis. Empleamos t\u00e9cnicas histoqu\u00edmicas para visualizar los n\u00facleos y tipos neuronales y t\u00e9cnicas inmunocitoqu\u00edmicas para detectar la presencia de las prote\u00ednas ligadoras de calcio. Encontramos una alteraci\u00f3n en las prote\u00ednas ligadoras de calcio observ\u00e1ndose una p\u00e9rdida de neuronas inmunopositivas que podr\u00edan explicar la desregulaci\u00f3n del calcio intrecelular producida durante la crisis. Con el objetivo de estudiar la distribuci\u00f3n de los neurotransmisores inhibidores gaba y glicina en el cerebro auditivo del h\u00e1mster gpg\/vall realizamos inmunocitoqu\u00edmica para estos neurotransmisores. No encontramos diferencias en la distribuci\u00f3n cualitativa de gaba y glicina pero s\u00ed un menor neuropilo inmunopositivo en el h\u00e1mster gpg\/vall y una disminuci\u00f3n de neuronas gaba \u00e9rgicas sobre todo en el ci. Para conocer que amino\u00e1cidos se encuentran alterados en el h\u00e1mster gpg\/vall aplicamos la t\u00e9cnicas de cromatograf\u00eda l\u00edquida de alta afinidad a muestras de cerebelo, tronco y col\u00edculos inferior y superior. observamos una disminuci\u00f3n  de los amino\u00e1cidos excitadores asp, glu y thr, pero principalmente del neurotransmisor inhibidor gaba. Esta mensor inhibici\u00f3n resultante podr\u00eda contribuir al estado dehiperexcitaci\u00f3n inherente al desencadenamiento de las crisis convulsiones. Numerosos estudios de lesi\u00f3n, farmacol\u00f3gicos y electrofisiol\u00f3gicos apuntan al col\u00edculo infe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del cerebro auditivo del hamster dorado \u00abmesocricetus auratus\u00bb normal y de la linea gpg\/vall<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del cerebro auditivo del hamster dorado \u00abmesocricetus auratus\u00bb normal y de la linea gpg\/vall <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ver\u00f3nica Fuentes Santamar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Estilita Lopez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Merch\u00e1n cifuentes Jaime a. <\/li>\n<li>Manuel S\u00e1nchez malmierca (vocal)<\/li>\n<li>joaqu\u00edn Rueda puente (vocal)<\/li>\n<li>Carlos De cabo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ver\u00f3nica Fuentes Santamar\u00eda La l\u00ednea de h\u00e1msters gpg\/vall empleada en el desarrollo de este trabajo presenta crisis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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