{"id":89369,"date":"2018-03-10T00:14:33","date_gmt":"2018-03-10T00:14:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-de-la-absorcion-percutanea-del-piroxicam-por-difusion-pasiva-e-iontoforesis-desarrollo-de-una-forma-topica-con-hidroxipropil-beta-ciclodextrina\/"},"modified":"2018-03-10T00:14:33","modified_gmt":"2018-03-10T00:14:33","slug":"estudio-in-vitro-de-la-absorcion-percutanea-del-piroxicam-por-difusion-pasiva-e-iontoforesis-desarrollo-de-una-forma-topica-con-hidroxipropil-beta-ciclodextrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-in-vitro-de-la-absorcion-percutanea-del-piroxicam-por-difusion-pasiva-e-iontoforesis-desarrollo-de-una-forma-topica-con-hidroxipropil-beta-ciclodextrina\/","title":{"rendered":"Estudio \u00abin vitro\u00bb de la absorci\u00f3n percutanea del piroxicam por difusi\u00f3n pasiva e iontoforesis: desarrollo de una forma topica con hidroxipropil-beta-ciclodextrina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Doliwa De La Iglesia Anna <\/strong><\/h2>\n<p>El piroxicam (px) es un aine con potente acci\u00f3n analg\u00e9sica, antipir\u00e9tica y antiinflamatoria, empleado en el tratamiento de la artritis reumatoide y otras afecciones inflamatorias. Este f\u00e1rmaco se absorbe bien por v\u00eda oral, aunque sus efectos adversos sobre la mucosa gastro intestinal pueden ser importantes. Por ello, para minimizar dichos efectos se ha planteado la posibilidad de administrar el f\u00e1rmaco por v\u00eda transd\u00e9rmica.  una manera de aumentar la absorci\u00f3n de sustancias a trav\u00e9s de la piel es la utilizaci\u00f3n de promotores de al absorci\u00f3n. En este trabajo, se ha a\u00f1adido a un gel hidrof\u00edlico de carbopol hidroxipropil-b-ciclodextrina, mediante la formaci\u00f3n de complejos de inclusi\u00f3n con el f\u00e1rmaco. Al formarse el complejo, se produce una disminuci\u00f3n tanto de la liberaci\u00f3n como de la absorci\u00f3n de px aunque dicho complejo (px:hpbcd) aumenta la solubilidad de px, lo que ha permitido aumentar la concentraci\u00f3n del f\u00e1rmaco en el gel.  adem\u00e1s, se ha empleado la t\u00e9cnica de la iontoforesis con el fin de conseguir una mayor absorci\u00f3n de f\u00e1rmaco. En todos los casos, la iontoforesis ha aumentado el flujo  de px 3,4 veces en comparaci\u00f3n con su flujo pasivo.  tambi\u00e9n se han llevado a cabo pretratamientos de la piel pasivos e iontofor\u00e9ticos con distintos terpenos (timolm mentona, 1,8-cineol) y se han determinado los flujos tanto pasivos como iontofor\u00e9ticos de px. El mayor valor del flujo del f\u00e1rmaco se consigue con un pretratamiento pasivo de la piel contimol al 5% seguido de la aplicaci\u00f3n de iontoforesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio \u00abin vitro\u00bb de la absorci\u00f3n percutanea del piroxicam por difusi\u00f3n pasiva e iontoforesis: desarrollo de una forma topica con hidroxipropil-beta-ciclodextrina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio \u00abin vitro\u00bb de la absorci\u00f3n percutanea del piroxicam por difusi\u00f3n pasiva e iontoforesis: desarrollo de una forma topica con hidroxipropil-beta-ciclodextrina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Doliwa De La Iglesia Anna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ygartua Ayerra M. Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Sanchez gonzalez <\/li>\n<li>alicia cristina L\u00f3pez castellano (vocal)<\/li>\n<li>anna cristina Calpena campmany (vocal)<\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Doliwa De La Iglesia Anna El piroxicam (px) es un aine con potente acci\u00f3n analg\u00e9sica, antipir\u00e9tica y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189,17749],"tags":[45124,45346,185987,43303,18204,185988],"class_list":["post-89369","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-navarra","tag-alicia-cristina-lopez-castellano","tag-anna-cristina-calpena-campmany","tag-doliwa-de-la-iglesia-anna","tag-juan-manuel-irache-garreta","tag-miguel-sanchez-gonzalez","tag-ygartua-ayerra-m-pilar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89369"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89369\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}