{"id":89474,"date":"2018-03-10T00:14:38","date_gmt":"2018-03-10T00:14:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antoanticuerpos-anti-ra33anti-factor-perinuclear-y-anti-keratina-en-la-artritis-reumatoide-un-analisis-inmunologico-genetica-y-clinico\/"},"modified":"2018-03-10T00:14:38","modified_gmt":"2018-03-10T00:14:38","slug":"antoanticuerpos-anti-ra33anti-factor-perinuclear-y-anti-keratina-en-la-artritis-reumatoide-un-analisis-inmunologico-genetica-y-clinico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/antoanticuerpos-anti-ra33anti-factor-perinuclear-y-anti-keratina-en-la-artritis-reumatoide-un-analisis-inmunologico-genetica-y-clinico\/","title":{"rendered":"Antoanticuerpos anti-ra33,anti-factor perinuclear y anti-keratina en la artritis reumatoide: un analisis inmunologico, genetica y clinico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Tarrio Juan  Manuel <\/strong><\/h2>\n<p>La artritis reumatoide es una enfermedad sistemica autoinmune de etiolog\u00eda desconocida.  los autoanticuerpos anti-ra33, anti-factor perinuclear (fap) y anti-keratina (aka) generados durante la respuesta inmune en la ar parecen asociarse con la patofisiolog\u00eda de la enfermedad. Los anti-ra33 detectan mediante t\u00e9cnicas de inmunoblot sobre extractos nucleares purificados de celulas hela las proteinas del complejo ra33(proteinas hnrnp-a2\/-ra33(36kd), b1(37kd) y b2(38 kd). Mediante t\u00e9cnias de inmunofluorescencia indirecta (ifi), los fap detectan gr\u00e1nulos perinucleares de queratohialina sobre celulas de la mucosa oral de donantes sanos, mientras que sobre cortes histol\u00f3gicos de es\u00f3fago de rata, los aka muestran una tinci\u00f3n laminar restringida al estrato c\u00f3rneo del tejido. Tanto en los 42 pacientes con ar en los estadios iniciales de la enfermedad, como en los 104 pacientes con ar establecida, los anticuerpos m\u00e1s especificos para el diagnostico de la ar fueron los aka(99%) y fap(94%). Su presencia en los pacientes con ar sin el fr es muy importante para \u00e9l diagnostico al inicio de la enfermedad. Los pacientes con ar positivos para fap y aka desarrollaron a los tres a\u00f1os de seguimiento una enfermedad mas severa. Los anticuerpos en aka desarrollaron a los tres a\u00f1os de seguimiento una enfermedad mas severa. Los anticuerpos en los pacientes con ar se asociaron con alelos hla-dr\/dq seg\u00fan diferentes perfiles: a)los alelos hla-drb1 con la secuencia de ep\u00edtopo compartido (ecp) q\/krraa se asociaron con la presencia de los anticuerpos fr y aka. Los aka tambien lo hacen con los genotipos que portan el ecp en homocigosis. B) el hla-dq8, se encuentran significativamente asociado con la presencia de los fap y aka. Ya que los fap y aka se definieron sobre sustratos de especies diferentes, nos centramos en la busqueda de una linea celular que exprese los antigenos definidos por los fap\/aka. Al investigar varias lineas celulares, la derivada de keati<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antoanticuerpos anti-ra33,anti-factor perinuclear y anti-keratina en la artritis reumatoide: un analisis inmunologico, genetica y clinico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antoanticuerpos anti-ra33,anti-factor perinuclear y anti-keratina en la artritis reumatoide: un analisis inmunologico, genetica y clinico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Tarrio Juan  Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rita Alvarez Doforno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: yolanda (secretario) Revilla novella <\/li>\n<li> Gomez de la concha Emilio (vocal)<\/li>\n<li>Emilio Martin mola (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Tarrio Juan Manuel La artritis reumatoide es una enfermedad sistemica autoinmune de etiolog\u00eda desconocida. los autoanticuerpos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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