{"id":89482,"date":"2018-03-10T00:14:38","date_gmt":"2018-03-10T00:14:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-estudio-estructural-y-farmacologico-de-nuevos-compuestos-azabica%c2%adclicos-y-azatrica%c2%adclicos-como-potenciales-antagonistas-5-ht3-y-o-agonistas-5-ht4\/"},"modified":"2018-03-10T00:14:38","modified_gmt":"2018-03-10T00:14:38","slug":"sa%c2%adntesis-estudio-estructural-y-farmacologico-de-nuevos-compuestos-azabica%c2%adclicos-y-azatrica%c2%adclicos-como-potenciales-antagonistas-5-ht3-y-o-agonistas-5-ht4","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesis-estudio-estructural-y-farmacologico-de-nuevos-compuestos-azabica%c2%adclicos-y-azatrica%c2%adclicos-como-potenciales-antagonistas-5-ht3-y-o-agonistas-5-ht4\/","title":{"rendered":"S\u00edntesis, estudio estructural y farmacol\u00f3gico de nuevos compuestos azabic\u00edclicos y azatric\u00edclicos como potenciales antagonistas 5-ht3 y\/o agonistas 5-ht4"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Villasante Prieto Francisco Javier <\/strong><\/h2>\n<p>En \u00e9sta memoria se ha llevado a cabo la s\u00edntesis de las siguientes series de compuestos como potenciales antagonistas 5-ht3 y\/o agonistas 5-ht4:  1,- ocho amidas derivadas del sistema de 1-azatriciclo (3.3.1.13,7)decano.  2,- catorce carbamatos derivados del sistema de 9-metil-9-azabiciclo(3.3.1)nonano.  3,- dos \u00e9steres derivados del sistema de 2-metil-2-azabiciclo(2.2.2)octano.  4,- dos ftalimidas n-sustituidas con los sistemas de 1-azabiciclo(2.2.2)octano y 8-metil-8-azabiciclo(3.2.1)octano.  adem\u00e1s se ha llevado a cabo el estudio de afinidad por los receptores 5-ht3 y 5-ht4 de la mayor\u00eda de estos compuestos, encontr\u00e1ndose datos significativos en cuatro de ellos, de los cuales el 4-amino-5-cloro-2-metil-2-azabiciclo(2.2.2)octan-6-anti-ilo ha resultado particularmente interesante debido a su elevada afinidad por el receptor 5-ht3 as\u00ed como por su manifiesta selectividad frente a otros receptores empleados en \u00e9ste estudio.  la tesis incluye tambi\u00e9n los resultados obtenidos en la aplicaci\u00f3n de diversas variantes de la reacci\u00f3n de strecker a la 1-azatriciclo(3.3.1.. 3,7)decan-4-ona. Estos resultados incluyen la obtenci\u00f3n de varios compuestos no descritos en la bibliograf\u00eda.  un aspecto importante dentro de \u00e9sta memoria es el estudio estructural de los compuestos obtenidos, recogi\u00e9ndose en la tesis hasta 4 estructuras obtenidas por difracci\u00f3n de rayos-x, as\u00ed como amplios estudios estructurales desarrollados por t\u00e9cnicas de resonancia magn\u00e9tica nuclear y espectroscop\u00eda de infrarrojos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis, estudio estructural y farmacol\u00f3gico de nuevos compuestos azabic\u00edclicos y azatric\u00edclicos como potenciales antagonistas 5-ht3 y\/o agonistas 5-ht4<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis, estudio estructural y farmacol\u00f3gico de nuevos compuestos azabic\u00edclicos y azatric\u00edclicos como potenciales antagonistas 5-ht3 y\/o agonistas 5-ht4 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Villasante Prieto Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Iriepa Canalda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fructuoso Barba valiente <\/li>\n<li>f\u00e9lix Hern\u00e1ndez cano (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Juan a Bellanato fontecha (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Villasante Prieto Francisco Javier En \u00e9sta memoria se ha llevado a cabo la s\u00edntesis de las siguientes 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