{"id":89558,"date":"2018-03-10T00:14:46","date_gmt":"2018-03-10T00:14:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/addicions-enantioselectives-de-dietilzinc-a-aldehids-i-imines-catalitzades-per-b-aminoalcohols-i-b-aminotiols\/"},"modified":"2018-03-10T00:14:46","modified_gmt":"2018-03-10T00:14:46","slug":"addicions-enantioselectives-de-dietilzinc-a-aldehids-i-imines-catalitzades-per-b-aminoalcohols-i-b-aminotiols","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/addicions-enantioselectives-de-dietilzinc-a-aldehids-i-imines-catalitzades-per-b-aminoalcohols-i-b-aminotiols\/","title":{"rendered":"Addicions enantioselectives de dietilzinc a aldehids i imines catalitzades per b-aminoalcohols i b-aminotiols."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ciril Jimeno Mollet <\/strong><\/h2>\n<p>Se ha sintetizado una nueva familia de b-aminoalcoholes mediante la apertura regioselectiva y estereoespec\u00edfica de epoxialcoholes quirales con aminas secundarias. Dichos epoxialcoholes se han obtenido mediante la epoxidaci\u00f3n catal\u00edtica enantioselectiva de sharpless, y tienen como principal caracter\u00edstica estructural un grupo alqu\u00edlico muy voluminoso (en concreto, un grupo terc-butilo o 1-adamantilo) en c3.  estos aminoalcoholes se han usado con \u00e9xito en la adici\u00f3n enantioselectiva de dietilzinc a aldeh\u00eddos, alcanzando elevadas conversiones y es de hasta el 96%.  adem\u00e1s, se han sintetizado diversos aminotioles partiendo de los aminoalcohoes preparados anteriormente. Al ser usados como ligandos en la adici\u00f3n de dietilzinc a aldehidos, han resultado ser a\u00fan mejores catalizadores, permitiendo preparar alcoholes secundarios con conversi\u00f3n total y enantioselectividades del 99%.  estos y otros ligandos sintetizados en nuestro grupo de investigaci\u00f3n han sido utilizados en una reacci\u00f3n poco desarrollada: la adici\u00f3n enantioselectiva de dietilzinc a iminas. Se ha descubierto que los mejores ligandos para esta reacci\u00f3n son muy parecidos estructuralmente a los catalizadores m\u00e1s eficientes en la adici\u00f3n a aldehidos, aunque ha sido necesario utilizar cantidades estequiom\u00e9tricas de b-aminoalcohol para obtener buenos resultados. adem\u00e1s, se ha observado que el uso de cloruros de cloruros de trialquilsililo mejora la reactividad de las iminas, por lo que una combinaci\u00f3n de aminoalcohol y cloruro de trialquilsililo ha permitido sintetizar aminas quirales con muy buenos rendimientos y elevadas purezas \u00f3pticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Addicions enantioselectives de dietilzinc a aldehids i imines catalitzades per b-aminoalcohols i b-aminotiols.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Addicions enantioselectives de dietilzinc a aldehids i imines catalitzades per b-aminoalcohols i b-aminotiols. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ciril Jimeno Mollet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Peric\u00c1\u00a0s Brondo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Bonjoch sese <\/li>\n<li>Jos\u00e9 Antonio Mayoral murillo (vocal)<\/li>\n<li>Antonio  m. Echavarren pablos (vocal)<\/li>\n<li>pedro Merino filella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ciril Jimeno Mollet Se ha sintetizado una nueva familia de b-aminoalcoholes mediante la apertura regioselectiva y estereoespec\u00edfica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,902,6775,17,416],"tags":[1384,186286,29016,1417,34338,42541],"class_list":["post-89558","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-estereoquimica-y-analisis-conformacional","category-organometalicos","category-quimica","category-quimica-organica","tag-antonio-m-echavarren-pablos","tag-ciril-jimeno-mollet","tag-jose-antonio-mayoral-murillo","tag-josep-bonjoch-sese","tag-miguel-angel-perica-s-brondo","tag-pedro-merino-filella"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89558"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89558\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}