{"id":89565,"date":"2018-03-10T00:14:46","date_gmt":"2018-03-10T00:14:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antiproteasas-en-la-enfermedad-inflamatoria-intestinal\/"},"modified":"2018-03-10T00:14:46","modified_gmt":"2018-03-10T00:14:46","slug":"antiproteasas-en-la-enfermedad-inflamatoria-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/antiproteasas-en-la-enfermedad-inflamatoria-intestinal\/","title":{"rendered":"Antiproteasas en la enfermedad inflamatoria intestinal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Canora Lebrato <\/strong><\/h2>\n<p>La enfermedad inflamatoria intestinal es una entidad que cursa en forma de brotes de actividad con periodos variables de ausencia de sintomas. ademas de las manifestaciones clinicas que sugieren un brote de la enfermedad, se ha intentado identificar que parametros analiticos, son utiles, por un lado, para identificar estas fases de actividad, y por otro, conocer la severidad de los brotes. Ya existen una serie de indices, aplicables bien a la enfermedad de crohn, bien a la colitis ulcerosa,que combinan datos clinicos, analiticos, endoscopicos, etc. Dificiles de interpretar y no siempre disponibles, que ayudan al esclarecimiento de estas cuestiones. no obstante, no existe ningun marcador analitico establecido y mayoritariamente aceptado, que por si solo, indique actividad y severidad de la enfermedad. por otro lado, hay una serie de proteinas, como son las antiproteasas, utiles en otras patolog\u00edas como la pancreatitis necr\u00f3tica, que tienen escasa actividad biologica, y que pudieran ser de utilidad en la identificaci\u00f3n de la fase activa de la enfermedad, en base a que por su mecanismo a que por su mecanismo de actuacion, se consumen en aquellos lugares donde exista inflamacion.  el objetivo de este estudio es demostrar que las antiproteasas est\u00e1n descendidas en la enfermedad inflamatoria intestinal y que adem\u00e1s, a mayor actividad y severidad del brote, la inflamaci\u00f3n local es mayor y por tanto, este descenso es mayor. Como objetivo secundario, queremos confirmar que las antiproteasas no sirven como marcadores biol\u00f3gicos de inflamaci\u00f3n.  para realizar este trabajo, se han estudiado pacientes diagnosticados de enfermedad inflamatoria intestinal, tanto de colitis ulcerosa como de enfermedad de crohn, clasificandolos a su vez en colitis ulcerosa leve, moderada y severa y enfermedad de crohn activa e inactiva, en base a los sistemas clasificatorios vigentes. Adem\u00e1s, hemos estudiado como grupo control, 18 sujetos sanos, de distribuci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antiproteasas en la enfermedad inflamatoria intestinal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antiproteasas en la enfermedad inflamatoria intestinal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Canora Lebrato <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rodr\u00edguez Cuartero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Rico irl\u00e9s <\/li>\n<li>Jos\u00e9 Vicente rull (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gomez capilla (vocal)<\/li>\n<li>Manuel Martin gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Canora Lebrato La enfermedad inflamatoria intestinal es una entidad que cursa en forma de brotes de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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