{"id":89592,"date":"2018-03-10T00:14:46","date_gmt":"2018-03-10T00:14:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relacion-entre-heterogeneidad-intragenomica-y-formacion-de-aberraciones-cromosomicas\/"},"modified":"2018-03-10T00:14:46","modified_gmt":"2018-03-10T00:14:46","slug":"relacion-entre-heterogeneidad-intragenomica-y-formacion-de-aberraciones-cromosomicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/relacion-entre-heterogeneidad-intragenomica-y-formacion-de-aberraciones-cromosomicas\/","title":{"rendered":"Relaci\u00f3n entre heterogeneidad intragen\u00f3mica y formaci\u00f3n de aberraciones cromos\u00f3micas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Puerto Navarro <\/strong><\/h2>\n<p>La asociaci\u00f3n entre des\u00f3rdenes gen\u00e9ticos y presencia de aberraciones cromos\u00f3micas, las convierte en marcadores de riesgo y justicia el inter\u00e9s en conocer los factores que pueden afectar su formaci\u00f3n. En la actualidad se considera que las aberraciones de tipo estrucutral (acs) se forman a partir de las roturas de doble cadena (dsbs) no reparadas o mal reparadas, de modo que todos los factores que afecten a la induci\u00f3n y\/o a su procesamiento afectaran a la formaci\u00f3n de las acs. Adem\u00e1s, la distribuci\u00f3n depender\u00e1 tambi\u00e9n de la persistencia de las acs. La persitencia de las acs es un requisito esencial en la evaluaci\u00f3n de las exposiciones cr\u00f3nicas o en los estudios retrospectivos, teniendo en cuenta que a partir de la frecuenica de acs se determina el nivel de exposici\u00f3n y el riesgo asociada a esta. en este sentido, la organizaic\u00f3n de la cromatina relacionada con la actividad g\u00e9nica podr\u00eda afectar la inducci\u00f3n, el procesamiento y la persistencia del da\u00f1o cromos\u00f3mico y por lo tanto, afectar la deistribuci\u00f3n de las acs.  en esta tesis doctoral se analiza in vivo e in vitro el efecto del tama\u00f1o y densidad g\u00e9nica de los cromosomas sobre la distribuci\u00f3n y persistencia de las acs; as\u00ed como el efecto de la estructura de la cromatina en la inducci\u00f3n, procesamiento y persistencia del da\u00f1o cromos\u00f3mico. En los diferentes estudios realizados, la distribuci\u00f3n de las acs se analiza bajo  diferentes condiciones de exposici\u00f3n, utilizando diferentes marcadores y modelos celulares en funci\u00f3n del objetivo concreto de cada estudio. La distribuci\u00f3n de las acs se analiza utilizando la t\u00e9cnica de fish.  los resultados obtendios indican que:  1,- la densidad g\u00e9nica y la longitud cromos\u00f3micas no son factores a tener en cuenta a la hora de seleccionar los cromosomas apartir de los cuales estimar la frecuencia de acs en estudios retrospectivos.  2,- existen diferencias intercromos\u00f3micas en la capacidad de reparaci\u00f3n por escisi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relaci\u00f3n entre heterogeneidad intragen\u00f3mica y formaci\u00f3n de aberraciones cromos\u00f3micas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relaci\u00f3n entre heterogeneidad intragen\u00f3mica y formaci\u00f3n de aberraciones cromos\u00f3micas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Puerto Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricard Marcos Dauder<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Garcia sagredo <\/li>\n<li>inmaculada Dominguez garcia (vocal)<\/li>\n<li>noel Xamena l\u00f3pez (vocal)<\/li>\n<li> Barquinero estruch joan francesc (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Puerto Navarro La asociaci\u00f3n entre des\u00f3rdenes gen\u00e9ticos y presencia de aberraciones cromos\u00f3micas, las convierte en marcadores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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