{"id":89605,"date":"2018-03-10T00:14:46","date_gmt":"2018-03-10T00:14:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-ciclosporina-a-vs-excipiente-sobre-un-modelo-experimental-de-autoinjerto-arterial-implicaciones-en-el-proceso-reparativo\/"},"modified":"2018-03-10T00:14:46","modified_gmt":"2018-03-10T00:14:46","slug":"efectos-de-la-ciclosporina-a-vs-excipiente-sobre-un-modelo-experimental-de-autoinjerto-arterial-implicaciones-en-el-proceso-reparativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-ciclosporina-a-vs-excipiente-sobre-un-modelo-experimental-de-autoinjerto-arterial-implicaciones-en-el-proceso-reparativo\/","title":{"rendered":"Efectos de la ciclosporina-a vs excipiente, sobre un modelo experimental de autoinjerto arterial. implicaciones en el proceso reparativo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca Jurado Moreno <\/strong><\/h2>\n<p>Dentro del proceso reparativo arterial que sigue a la lesi\u00f3n total o parcial de la pared vascular, la aparici\u00f3n de la hiperplasia intimal (neo\u00edntima), constituye uno de los hechos m\u00e1s relevantes. Este proceso, que consiste en la proliferaci\u00f3n de c\u00e9lulas musculares lisas y s\u00edntesis de matriz extracelular a nivel subintimal, causa con frecuencia estenosis y trombosis del vaso, y conduce al fracaso del mismo.  los linfocitos t est\u00e1n implicados en al aparici\u00f3n de la neo\u00edntima como agentes productores o inductores de la g\u00e9nesis de factores mitog\u00e9nicos para c\u00e9lulas musculares lisas y otras estirpes celulares. Nuestro objetivo fue comprobar si la inmunosupresi\u00f3n pod\u00eda inhibir el desarrollo de la hiperplasia intimal, en un modelo experimental de autoinjerto arterial desarrollado en rata spargue-dawley hembra, utilizando como agente inmunosupresor la ciclosporina-a (csa).  el estudio se plante\u00f3 en dos pautas diferentes:  a,- preoperatoria, administrando la csa durante 4 d\u00edas previos a la intervenci\u00f3n quir\u00fargica.  b,- cont\u00ednua, iniciando el tratamiento el mismo d\u00eda que en el caso anterior y continu\u00e1ndolo hasta el sacrificio a 7,14,21,30 y 50 d\u00edas post-implante.  dise\u00f1amos tres grupos de estudio:  grupo i (control, n=20), animales intervenidos y sin tratamiento  grupo ii (csa-cp, n=40), animales intervenidos y tratados con sandimun(r) (csa vehiculizada en un agente oleaginoso, cremophor(r)) en una dosis de 5 mg\/kg\/d\u00eda, v\u00edas s.C.  grupo iii (csa-et, n=40), animales intervenidos y tratados con csa pura, utilizando etanol como excipiente.  se realizaron estudios morfol\u00f3gico y ultraestructural (microscop\u00eda \u00f3ptica y electr\u00f3nica de transmisi\u00f3n y barrido), de proliferaci\u00f3n celular (autorradiogr\u00e1fia con timidina-h3), inmunohistoqu\u00edmico (anticuerpos espec\u00edficos para linfocitos t cd4+ y cd8+, monocitos\/macr\u00f3fago ed1+, alfa-actina de m\u00fasculo liso, factor von willebrand (wf), elastina, elastasa neutrof\u00edlica y meta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la ciclosporina-a vs excipiente, sobre un modelo experimental de autoinjerto arterial. implicaciones en el proceso reparativo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la ciclosporina-a vs excipiente, sobre un modelo experimental de autoinjerto arterial. implicaciones en el proceso reparativo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca Jurado Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julia Bujan Varela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eliseo Carrascal marino <\/li>\n<li>pablo Ortiz pedro (vocal)<\/li>\n<li>tom\u00e1s Garc\u00eda caballero parada (vocal)<\/li>\n<li>Fernando Tur\u00e9gano fuentes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca Jurado Moreno Dentro del proceso reparativo arterial que sigue a la lesi\u00f3n total o parcial de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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