{"id":89610,"date":"2018-03-10T00:14:50","date_gmt":"2018-03-10T00:14:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-posible-neurotoxicidad-del-tratamiento-cronico-con-levodopa-versus-pergolida-en-un-modelo-experimental-de-enfermedad-de-parkinson-en-rata\/"},"modified":"2018-03-10T00:14:50","modified_gmt":"2018-03-10T00:14:50","slug":"estudio-de-la-posible-neurotoxicidad-del-tratamiento-cronico-con-levodopa-versus-pergolida-en-un-modelo-experimental-de-enfermedad-de-parkinson-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-posible-neurotoxicidad-del-tratamiento-cronico-con-levodopa-versus-pergolida-en-un-modelo-experimental-de-enfermedad-de-parkinson-en-rata\/","title":{"rendered":"Estudio de la posible neurotoxicidad del tratamiento cr\u00f3nico con levodopa versus pergolida en un modelo experimental de enfermedad de parkinson en rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  R\u00edo Garc\u00eda Lydia Del <\/strong><\/h2>\n<p>Se ha realizado un estudio in vivo que compara el efecto de la administraci\u00f3n de levodopa y la pergolida en la superviviencia de neuronas de la sustancia negra compacta (snc) en ratas con lesi\u00f3n parcial nigroestriada.  todos los grupos de animales se lesionaron con 4ug de 6-ohda para producir una lesi\u00f3n parcial de la snc izquierda. Grupos: grupo i, se sacrific\u00f3 a las 4 semanas de la inyecci\u00f3n; grupo ii (0,5 ml de salino); grupos iii, iv y v tratados con levodopa+benserazida (l+b) (50,100 y 150 mg\/kg); grupos vi, vii y viii tratados con pergolida (0.5, 1 y 3 mg\/kg).Todos los grupos (i-viii) se sacrificarona las 24 horas de la \u00faltima dosis. Tres grupos de animales (ix, x y xi) tratados con salino, 50 mg\/kg de l+b y 1 mg\/kg de pergolida se sacrificaron a los 7 d\u00edas de la ultima dosis. Los tratamientos fueron diarios y de 8 semanas de duraci\u00f3n.  el n\u00famero de c\u00e9lulas th-ir fue significativamente menor en el grupo de animales tratados con las diferentes dosis de l+b cuando se compararon con los grupos que recibieron salino o pergolida. Sin embargo, tras el lavado faracol\u00f3gico, el grupo x present\u00f3 igual n\u00famero de c\u00e9lulas th-ir que el grupo ix pero inferior al grupo xi. Se observ\u00f3 una reducci\u00f3n en los niveles de da, dopac y hva en el estriado denervadode todos lo grupos. el \u00edndice aopot\u00f3ticom\u00e1s alto se encontr\u00f3 en los grupos sacrificados 4 semanas despu\u00e9s  de la lesi\u00f3n y en los tratados con l+b. Los animales tratados con pergolida presentaron el \u00edndice apopt\u00f3tico m\u00e1s bajo.  se observ\u00f3 un mayor n\u00famero de c\u00e9lulas (+) para la hibridaci\u00f3n in situ que c\u00e9lulas th-ir en los animales tratados con 50 mg\/kg de l+b surgiriendo un efecto de la levodopa sobre la expresi\u00f3n de la enzima th.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la posible neurotoxicidad del tratamiento cr\u00f3nico con levodopa versus pergolida en un modelo experimental de enfermedad de parkinson en rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la posible neurotoxicidad del tratamiento cr\u00f3nico con levodopa versus pergolida en un modelo experimental de enfermedad de parkinson en rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  R\u00edo Garc\u00eda Lydia Del <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Rosario Luquin Piudo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Velayos jos\u00e9 <\/li>\n<li>Jos\u00e9 Catal\u00e1n M\u00aa (vocal)<\/li>\n<li>Mar\u00eda \u00e1ngela Burrell bustos (vocal)<\/li>\n<li>felix Javier Jim\u00e9nez jim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de R\u00edo Garc\u00eda Lydia Del Se ha realizado un estudio in vivo que compara el efecto de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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