{"id":8962,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-la-senalizacion-intracelular-de-las-citoquinas-1l-beta-y-tnf-alfa-en-la-celula-granulosa-ovarica\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-la-senalizacion-intracelular-de-las-citoquinas-1l-beta-y-tnf-alfa-en-la-celula-granulosa-ovarica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-senalizacion-intracelular-de-las-citoquinas-1l-beta-y-tnf-alfa-en-la-celula-granulosa-ovarica\/","title":{"rendered":"Estudio de la se\u00f1alizacion intracelular de las citoquinas 1l-beta y tnf-alfa en la celula granulosa ovarica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Llanes Menendez M. Luz <\/strong><\/h2>\n<p>En celulas granulosa del ovario de ratas inmaduras diferenciadas \u00abin vitro\u00bb, se midieron los niveles de actividad y expresion de los enzimas limitantes de la esteroidogenesis y de la sintesis de prostaglandinas y la acumulacion de esteroides y prostaglandina e2 en respuesta a las citoquinas il-1 beta y tnf alfa y la acumulacion de ceramida producida por una smasa exogena o la administracion del analogo permeable de la ceramida (c2-cer), los cuales reprodujeron los conocidos efectos inhibitorios sobre la esteroidogenesis de ambas citoquinas e indujeron la expresion del enzima limitante de la sintesis de prostaglandinas aunque no reprodujeron en su totalidad los efectos sobre la acumulacion de prostaglandina e2.En conjunto, los datos obtenidos sustentan la hipotesis de que los receptores de la il-1 beta y el tnf alfa estan acoplados en la celula granulosa del ovario a una smasa, y que el producto de la activacion de la misma, la ceramida, es el mensajero intracelular de los efectos de las citoquinas en estas celulas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la se\u00f1alizacion intracelular de las citoquinas 1l-beta y tnf-alfa en la celula granulosa ovarica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la se\u00f1alizacion intracelular de las citoquinas 1l-beta y tnf-alfa en la celula granulosa ovarica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Llanes Menendez M. Luz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luisa Fernanda Fanjul Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Aguilar Benitez De Lugo <\/li>\n<li>Carlos Dieguez Gonzalez (vocal)<\/li>\n<li>Francisco Estevez Rosas (vocal)<\/li>\n<li>Eleuterio Hernandez Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Llanes Menendez M. Luz En celulas granulosa del ovario de ratas inmaduras diferenciadas \u00abin vitro\u00bb, se midieron [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,851,139,16629],"tags":[15487,17535,2380,31111,31109,31110],"class_list":["post-8962","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endocrinologia","category-medicina-interna","category-palmas-de-gran-canaria","tag-carlos-dieguez-gonzalez","tag-eleuterio-hernandez-miguel","tag-enrique-aguilar-benitez-de-lugo","tag-francisco-estevez-rosas","tag-llanes-menendez-m-luz","tag-luisa-fernanda-fanjul-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=8962"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/8962\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=8962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=8962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=8962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}