{"id":89659,"date":"2001-03-04T00:00:00","date_gmt":"2001-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-patogenicos-de-las-lesiones-gastrointstinales-inducidas-por-meloxicam-y-prioxicam\/"},"modified":"2001-03-04T00:00:00","modified_gmt":"2001-03-04T00:00:00","slug":"mecanismos-patogenicos-de-las-lesiones-gastrointstinales-inducidas-por-meloxicam-y-prioxicam","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-patogenicos-de-las-lesiones-gastrointstinales-inducidas-por-meloxicam-y-prioxicam\/","title":{"rendered":"Mecanismos patog\u00e9nicos de las lesiones gastrointstinales inducidas por meloxicam y prioxicam"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Villegas Lama M. Isabel <\/strong><\/h2>\n<p>Los antiinflamatorios no esteroideos o aine se encuntran entre los f\u00e1rmacos m\u00e1s consumidores en todo el mundo. Sin embargo, el suso de estos agentes se acompa\u00f1a de efectos secundarios que pueden aparecer hasta en el 25% de los pacientes, siendo los relacionados con el tracto digestivo un n\u00famero importante.  nuestro estudio ha sido realizado utilizando dos f\u00e1rmacos con diferente grado de selectividad por las isoformas de la ciclooxigenasa (cox): piroxicam (prx) como inhibidor preferente de cox-1 y meloxicam (mlx) como inhibidor preferente de cox-2 (la especificidad cox-2 implica que un agente con esta propiedad proporcionar\u00e1 beneficios apreciables comparado con los aine convencionales), con un doble objetivo: valorar el perfil de toxicidad gastrointestinal de estos dos agentes, tras administraci\u00f3n aguda y reiterada en rata, e investigar los posibles mecanismos implicados en la gastroenteopat\u00eda inducida.  en funci\u00f3n de los resultados obtenidos, podemos concluir que:  &#8211; mlx y prx producen una ca\u00edda significativa y dosis-dependiente de la concentraci\u00f3n de prostaglandina (pg)-e2 en la mucosa g\u00e1strica, que es inversamente proporcional a la magnitud de las lesiones. A dosis equipotentes, prx demostr\u00f3 ser un inhibidor de la s\u00edntesis de pg m\u00e1s eficaz.  &#8211; los tratamientos combiandos de los aine y hc1 aumentan considerablemente la intensidad de las lesiones, lo que coincide con un descenso de la concentraci\u00f3n de pge2 en la mucosa, que es pr\u00e1cticamente igual con ambos tratamientos. el hecho de que tanto el inhibidor preferente de cox-2 (mlx) como el inhibidor prererente de cox-1 (prx) provoquen estas respuestas, sugiere que las pg generadas por ambas isoenzimas representan un papel destacado en la reparaci\u00f3n del da\u00f1o.  &#8211; las lesiones g\u00e1stricas inducidas por prx se asocian con incrementos estad\u00edsticamente signficativos de la actividad mpo y de la producci\u00f3n de la citoquina proinflamatoria tnf-a. Por el contrario, mlx no modif<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos patog\u00e9nicos de las lesiones gastrointstinales inducidas por meloxicam y prioxicam<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos patog\u00e9nicos de las lesiones gastrointstinales inducidas por meloxicam y prioxicam <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Villegas Lama M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00edn Calero M. Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rabasco alvarez <\/li>\n<li> Ayuso gonz\u00e1lez M\u00aa Jes\u00fas (vocal)<\/li>\n<li>Miguel Pay\u00e1 peris (vocal)<\/li>\n<li>\u00e1ngel Lanas arbeola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Villegas Lama M. Isabel Los antiinflamatorios no esteroideos o aine se encuntran entre los f\u00e1rmacos m\u00e1s consumidores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,155,9,2445,189,957,483,384,10715],"tags":[45550,11840,76422,55488,63235,186447],"class_list":["post-89659","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-clinicas","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacodinamia","category-farmacologia","category-mecanismos-de-accion-de-los-farmacos","category-patologia-clinica","category-sevilla","tag-angel-lanas-arbeola","tag-antonio-rabasco-alvarez","tag-ayuso-gonzalez-ma-jesus","tag-martin-calero-m-jose","tag-miguel-paya-peris","tag-villegas-lama-m-isabel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89659"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89659\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}