{"id":89663,"date":"2001-03-04T00:00:00","date_gmt":"2001-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/telomerasa-regulacion-diana-terapeutica-y-significado-cla%c2%adnico-en-neoplasias-humanas\/"},"modified":"2001-03-04T00:00:00","modified_gmt":"2001-03-04T00:00:00","slug":"telomerasa-regulacion-diana-terapeutica-y-significado-cla%c2%adnico-en-neoplasias-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/telomerasa-regulacion-diana-terapeutica-y-significado-cla%c2%adnico-en-neoplasias-humanas\/","title":{"rendered":"Telomerasa: regulaci\u00f3n, diana terap\u00e9utica y significado cl\u00ednico en neoplasias humanas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Albanell Mestres <\/strong><\/h2>\n<p>Las c\u00e9lulas malignas deben adquirir un potencial de replicaci\u00f3n ilimitado (inmortalidad celular) para la formaci\u00f3n de tumores avanzados. La adquisici\u00f3n de inmortalidad celular depende de la reactivaci\u00f3n de la telomerasa, una enzima que permite compensar el problema de replicaci\u00f3n terminal del adn asociado a cada divisi\u00f3n celular. En una serie de estudios presentados en esta tesis, se demuestra;  1,- la telomerasa es una enzima regulable en c\u00e9lulas tumorales humanas. la maduraci\u00f3n de c\u00e9lulas neopl\u00e1sicas de diversa estirpe inducida por agentes diferenciadores se asocia a inhibici\u00f3n de telomerasa. El grado de inhibici\u00f3n  de telomersas se correlaciona inversamente con el grado de diferenciaci\u00f3n celular en los modelos experimentales. Esta correlaci\u00f3n inversa existe tambi\u00e9n in vivo en tumores de c\u00e9lulas germinales.  2,- los tumores humanos expresan actividad telomerasa y su expresi\u00f3n se asocia a estad\u00edo tumoral, \u00edndice proliferativo y diferenciaci\u00f3n. Los c\u00e1nceres de pulm\u00f3n con alto nivel de telomerasa se asocian a un alto \u00edndice proliferativo y con estad\u00edos avanzados. Estos hallazgos indican que la actividad telomerasa puede contribuir a la tumorig\u00e9nesis pulmonar y a su profesi\u00f3n. En tumores de c\u00e9lulas germinales masculinos, la actividad telomersa se expresa en todos los c\u00e1nceres de c\u00e9lulas germinales. En cambio, no se detecta en ning\u00fan teratoma madura. Estos hallazgos indican que existe una correlaci\u00f3n inversa in vivo entre actividad de telomerssa y el estado de diferenciaci\u00f3n de los tumores de c\u00e9lulas germinales.  3,- la telomerasa es una diana antitumoral atractiva. La mayor\u00eda de tumores expresan actividad telomerasa mientras que los tejidos normales adyacentes carecen de actividad detectable. Esta observaci\u00f3n apoya el concepto de inhibici\u00f3n de telomerasa como una terapia atractiva del c\u00e1ncer porque deber\u00eda contar con dos caracter\u00edsticas importantes; amplio espectro antitumoral y escasa toxicidad. E<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Telomerasa: regulaci\u00f3n, diana terap\u00e9utica y significado cl\u00ednico en neoplasias humanas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Telomerasa: regulaci\u00f3n, diana terap\u00e9utica y significado cl\u00ednico en neoplasias humanas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Albanell Mestres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Baselga Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Guardia mass\u00f3 <\/li>\n<li>joaquin Arribas l\u00f3pez (vocal)<\/li>\n<li>anna Lluch hern\u00e1ndez (vocal)<\/li>\n<li> Bosch gil josep \u00e1ngel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Albanell Mestres Las c\u00e9lulas malignas deben adquirir un potencial de replicaci\u00f3n ilimitado (inmortalidad celular) para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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