{"id":89759,"date":"2001-06-04T00:00:00","date_gmt":"2001-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-molecular-de-la-activacion-de-la-oxido-nitrico-sintasa-inducible-humana-mediada-por-los-virus-b-y-c-de-la-hepatitis\/"},"modified":"2001-06-04T00:00:00","modified_gmt":"2001-06-04T00:00:00","slug":"analisis-molecular-de-la-activacion-de-la-oxido-nitrico-sintasa-inducible-humana-mediada-por-los-virus-b-y-c-de-la-hepatitis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-molecular-de-la-activacion-de-la-oxido-nitrico-sintasa-inducible-humana-mediada-por-los-virus-b-y-c-de-la-hepatitis\/","title":{"rendered":"Analisis molecular de la activaci\u00f3n de la \u00f3xido nitrico sintasa inducible humana mediada por los virus b y c de la hepatitis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M.jose Amaro Alonso <\/strong><\/h2>\n<p>En estudios previos se ha comprobado que en el higado de pacientes infectados con hepatitis cronicas viricas, hay un aumento del mrna de la \u00f3xido nitrico sintasa inducible (inos), enzima responsable de la sintesis del oxido nitrico (no) en los hepatocitos. Sin embargo, los mecanismos moleculares responsbles de este aumento en la transcripci\u00f3n del gen de la inos se desconoce. En la presente tesis doctoral, mediante el an\u00e1lisis de los niveles de mrna de la inos, estudios de transactivacion del promotor y ensayos de retardo de la movilidad electrofor\u00e9tica, se ha demostrado que la proteina px del virus b de la hepatitis y la proteina core del virus c de la hepatitis transactivan el promotor de la inos hep\u00e1tica a traves de la via de se\u00f1alizacion del factor de transcripci\u00f3n nf-kb.  el aumento de los niveles del no como consecuencia de la activaci\u00f3n de la inos en las infecciones por ambos virus, podria tener importantes consecuencias patofisiologicas. En primer lugar, el no provoca la disminuci\u00f3n de la sintesis tanto de proteinas viricas como celulares, lo cual podria ayudar a estos virus a escapar a su detecci\u00f3n por el sistema inmunol\u00f3gico, contribuyendo a la cronificaci\u00f3n de estas infecciones. Por otro lado, niveles altos de no pueden alterar diversas proteinas y lipidos celulares, contribuyendo al da\u00f1o hepatico en los pacientes con hepatitis cronicas viricas. Por \u00fatlimo, el incremento en lo niveles intrahepatocitarios de no puede tener importantes consecuencias en relaci\u00f3n al desarrollo de hepatocarcinoma, ya que el no puede da\u00f1ar directamente el dna celular, inhibir los sistemas reparadores del da\u00f1o en el dna celular, inhibir la apoptosis e inducir cambios conformacionales y funcionales en la proteina supresora de tumores p53.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis molecular de la activaci\u00f3n de la \u00f3xido nitrico sintasa inducible humana mediada por los virus b y c de la hepatitis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis molecular de la activaci\u00f3n de la \u00f3xido nitrico sintasa inducible humana mediada por los virus b y c de la hepatitis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M.jose Amaro Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Gosalvez garcia <\/li>\n<li>arturo Fernandez cruz (vocal)<\/li>\n<li>guillermna Barril cuadrado (vocal)<\/li>\n<li>Elena Rodriguez i\u00f1igo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M.jose Amaro Alonso En estudios previos se ha comprobado que en el higado de pacientes infectados con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,280],"tags":[723,30166,186609,186608,186606,186607],"class_list":["post-89759","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-virologia","tag-arturo-fernandez-cruz","tag-elena-rodriguez-inigo","tag-guillermna-barril-cuadrado","tag-jaime-gosalvez-garcia","tag-m-jose-amaro-alonso","tag-vicente-carreno"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89759"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89759\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}