{"id":89814,"date":"2018-03-10T00:15:04","date_gmt":"2018-03-10T00:15:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-sesquiterpenolidas-biosintetizadas-por-plantas-de-la-familia-de-las-umbeliferas\/"},"modified":"2018-03-10T00:15:04","modified_gmt":"2018-03-10T00:15:04","slug":"sintesis-de-sesquiterpenolidas-biosintetizadas-por-plantas-de-la-familia-de-las-umbeliferas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-sesquiterpenolidas-biosintetizadas-por-plantas-de-la-familia-de-las-umbeliferas\/","title":{"rendered":"Sintesis de sesquiterpenolidas biosintetizadas por plantas de la familia de las umbeliferas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Aladro Prieto <\/strong><\/h2>\n<p>Las lactonas sesquiterpenicas constituyen un grupo de productos naturales caracterizados por poseer un alto numero de actividades biol\u00f3gicas, siendo la familia de las compuestas sus principal fuente. Aparte de este familia, las umbel\u00edferas aportan lactonas con un patr\u00f3n esteroquimico caracteristico, consistente en un anillo 11alfa-hidroxi-cis-beta, beta-gamma-lactona en lugar en lugar del anillo trans-alfa-metilen-gamma-lactona mostrada por las lactonas aisladas de compuestas.  desde un punto de vista sintetico, existen varios antecedentes en la sintesis de este tipo de compuestos que muestran como principales incovenientes la dificil introducci\u00f3n del grupo hidroxilo en c11(posicion alfa al carbonilo del anillo lact\u00f3nico) y la reducci\u00f3n de un carbonilo en c6 en el anillo de eudesmano al grupo hidroxilo necesario para el cierre del anillo lact\u00f3nico. a estas dificultades, se a\u00f1aden los intentos fallidos de elaboraci\u00f3n del anillo c a partir de un sistema 1,2 diol sin fragmentaci\u00f3n del enlace c-c.  en la presente memoria se describe un nuevo procedimiento de sintesis de este tipo de compuestos que evita los inconvenientes anteriormente citados. por una parte, la nueva metodolog\u00eda consta de un m\u00e9todo de hidroxilacion selectiva en posiciones al\u00edlicas que permite el acceso a la posicion c6 del anillo precursor del eudesmano sin proceder de la reducci\u00f3n del carbonilo en dicha posici\u00f3n, discuti\u00e9ndose los requerimientos estructurales necesarias para la aplicaci\u00f3n satisfactoria de la reaccion. Por otra parte, la obtenci\u00f3n del anillo lact\u00f3nico se efect\u00faa por oxidaci\u00f3n de un sistema isopropenilo a sistema 1,2-glicol y posterior oxidaci\u00f3n a alfa-hidroxi\u00e1cido sin ruptura del enlace c-c del sistema diol.  la aplicaci\u00f3n de los procedimientos anteriores lleva a la s\u00edntesis enantioselectiva de las lactonas sesquiterp\u00e9nicas: 11alfa-angeloiloxi-3-oxo-6alfah,7alfah, 10alfame-eudesman-1,2-4,5-dien-6,12-olida y de su epimero 11alfa-tigl<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de sesquiterpenolidas biosintetizadas por plantas de la familia de las umbeliferas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de sesquiterpenolidas biosintetizadas por plantas de la familia de las umbeliferas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Aladro Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Mart\u00ednez Massanet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alejandro Fernandez barrero <\/li>\n<li>pilar Areces bravo (vocal)<\/li>\n<li>mohamed Akssira (vocal)<\/li>\n<li>ricardo Alonso alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Aladro Prieto Las lactonas sesquiterpenicas constituyen un grupo de productos naturales caracterizados por poseer un 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