{"id":89820,"date":"2018-03-10T00:15:04","date_gmt":"2018-03-10T00:15:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-taurina-induce-y-modula-la-plasticidad-sinaptica-estudio-de-los-mecanismos-implicados\/"},"modified":"2018-03-10T00:15:04","modified_gmt":"2018-03-10T00:15:04","slug":"la-taurina-induce-y-modula-la-plasticidad-sinaptica-estudio-de-los-mecanismos-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-taurina-induce-y-modula-la-plasticidad-sinaptica-estudio-de-los-mecanismos-implicados\/","title":{"rendered":"La taurina induce y modula la plasticidad sin\u00e1ptica: estudio de los mecanismos implicados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Del Olmo Izquierdo <\/strong><\/h2>\n<p>La aplicaci\u00f3n de 5-10mm de taurina durante 20-30 min a las rodajas de hipocampo genra una potenciaci\u00f3n de la eficacia sin\u00e1ptica de la regi\u00f3n ca1 que dura al menos tres horas despu\u00e9s del lavado del amino\u00e1cido y que hemos denominado llp-tau. Esta potenciaci\u00f3n es independiente de los receptores gabaa y de los receptores ionotr\u00f3picos de glutamanto. El establecimiento de la llp-tau requiere de un aumento de calcio intracelular que proviene de dos fuentes; el medio extracelular y el calcio almacenado en los acervos intracelulares del ret\u00edculo endopl\u00e1smico.La entrada de calcio desde el espacio extracelular parece ser debida a la activaci\u00f3n de unos canales de calcio que se activan por peque\u00f1os cambios de voltaje.  el aumento de calcio intracelular es un requerimiento esencial en el establecimiento de otros tipos de potenciaciones sin\u00e1pticas entre las que destaca la potenciaci\u00f3n inducida por la estimulaci\u00f3n de alta frecuencia (ltp), ya que se activan una serie de procesos enzim\u00e1ticos dependientes de calcio que son los responsables dela potenciaci\u00f3n. La ltp y la llp-tau se concluyen mutuamente,lo que indica que en ambos fen\u00f3menos existen mecanismso moleculares comunes. Cuando estudiamos si las prote\u00ednas quinasas implicadas en la ltp eran necesarias para el establecimiento de la llp-tau, llegamos a la conclusi\u00f3n de que es la prote\u00edna quinasa dependiente de ampc (pka), el mecanismo enzim\u00e1tico com\u00fan a ambos fen\u00f3menos. La puesta en marcha de la pka conlleva la activaci\u00f3n de la s\u00edtnesis proteica gener\u00e1ndose as\u00ed nuevas prote\u00ednas imprescindibles para que la llp-tau se convierta en un fen\u00f3meno duradero. El aumento en la s\u00edntesis proteica parece estar mediado por un aumento en la forma fosforilada del factor de transcripci\u00f3n creb, a pesar de que la perfusi\u00f3n de taurina no aumenta los niveles de ampc.  tambi\u00e9n quisimos conocer si la potenciaci\u00f3n sin\u00e1ptica inducida por taurina era debida al aumento intracelular del amino\u00e1c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La taurina induce y modula la plasticidad sin\u00e1ptica: estudio de los mecanismos implicados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La taurina induce y modula la plasticidad sin\u00e1ptica: estudio de los mecanismos implicados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Del Olmo Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Sol\u00eds Torralba Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: asunci\u00f3n Colino matilla <\/li>\n<li>pedro De  la villa polo (vocal)<\/li>\n<li>washington Bu\u00f1o buceta (vocal)<\/li>\n<li>angel Nu\u00f1ez molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Del Olmo Izquierdo La aplicaci\u00f3n de 5-10mm de taurina durante 20-30 min a las rodajas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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