{"id":89843,"date":"2018-03-10T00:15:04","date_gmt":"2018-03-10T00:15:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-patogenetico-del-factor-de-activacion-plaquetaria-y-el-oxido-nitrico-endogeno-en-el-asma-bronquial\/"},"modified":"2018-03-10T00:15:04","modified_gmt":"2018-03-10T00:15:04","slug":"papel-patogenetico-del-factor-de-activacion-plaquetaria-y-el-oxido-nitrico-endogeno-en-el-asma-bronquial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-patogenetico-del-factor-de-activacion-plaquetaria-y-el-oxido-nitrico-endogeno-en-el-asma-bronquial\/","title":{"rendered":"Papel patogenetico del factor de activacion plaquetaria y el oxido nitrico endogeno en el asma bronquial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Gomez Federico <\/strong><\/h2>\n<p>Distintas evidencias sugieren que el factor de activaci\u00f3n plaquetaria (paf)y el \u00f3xido nitrico (no) estarian involucradas en la patogenesis del asma bronquial. El paf provocaria broncoconstricci\u00f3n y alteraciones en el intercambio gaseoso en relaci\u00f3n al incremento de la permeabilidad vascular bronquial y la producci\u00f3n secundaria de leucotrienos (lts). El no no es potente vasodilatador end\u00f3geno que podr\u00eda contribuir a la formaci\u00f3n de edema y mayor estrechamiento de la luz de lasv\u00edas aereas y afectaria el mecanismo fisiol\u00f3gico de vasoconstricci\u00f3n pulmonar hipoxica alterando el intercambio gaseoso. Los objetivos de esta tesis fueron investigar el papel patogenico del paf y el no asi como interacciones entre el paf y los lts en las alteracionies del intercambio gaseoso en el asma bronquial mediante el estudio de los efectos de distintos antagonistas de estos mediadores.  fueron realizado 5 estudios doble ciego y controlados en pacientes con asma bronquial. En los dos primeros trabajos se investigaron los efectos de un potente antagonista de los receptores del paf (sr27417a) en un modelo experimental de broncoprovocaci\u00f3n con paf (primer estudio) y en pacientes hospitalizados por asma aguda (segundo estudio). En el tercer estudio se evaluaron los efectos de un antagonista de la 5-lipoxigenasa en pacientes broncoprovocados con paf. El cuarto estudio, consisti\u00f3 en una evaluaci\u00f3n metodol\u00f3gica de la medici\u00f3n del no en el aire exhalado. Por \u00faltimo, en el quinto estudio se evaluaron la correlaci\u00f3n entre el no exhalado y el estado de las relaciones ventilaci\u00f3n-perfusi\u00f3n (va\/q) en condiciones basales y los cambios producidos por la inhibici\u00f3n de la s\u00edntesis de no con l-name nebulizado. Conclusiones: 1)el ser-27417a es un antagonista eficaz de los efectos sist\u00e9maticos, celulares y de las alteraciones en el intercambio de gases producidos por la broncoprovocaci\u00f3n con paf en pacientes con asma leve. Por el contrario, la adici\u00f3n de sr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel patogenetico del factor de activacion plaquetaria y el oxido nitrico endogeno en el asma bronquial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel patogenetico del factor de activacion plaquetaria y el oxido nitrico endogeno en el asma bronquial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Gomez Federico <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Albert Barber\u00e1 Mir<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ferran Morell brotad <\/li>\n<li>miquel Felez flor (vocal)<\/li>\n<li>pere Gines gibert (vocal)<\/li>\n<li>joaquin Gea guiral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Gomez Federico Distintas evidencias sugieren que el factor de activaci\u00f3n plaquetaria (paf)y el \u00f3xido nitrico (no) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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