{"id":89902,"date":"2018-03-10T00:15:09","date_gmt":"2018-03-10T00:15:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-responsables-del-fenomeno-de-la-tolerancia-al-lipolisacarido-de-escherichia-coli-en-monocitos-humanos\/"},"modified":"2018-03-10T00:15:09","modified_gmt":"2018-03-10T00:15:09","slug":"mecanismos-responsables-del-fenomeno-de-la-tolerancia-al-lipolisacarido-de-escherichia-coli-en-monocitos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-responsables-del-fenomeno-de-la-tolerancia-al-lipolisacarido-de-escherichia-coli-en-monocitos-humanos\/","title":{"rendered":"Mecanismos responsables del fenomeno de la tolerancia al lipolisacarido de escherichia coli en monocitos humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vazquez Araujo M. Bego\u00f1a <\/strong><\/h2>\n<p>La respuesta monocitaria  a un estimulo con lipopolisac\u00e1rido (lps) es la producci\u00f3n de diferentes tipos de mediadores solubles. Entre ellos, los m\u00e1s caracteristicos son citoquinas proinflamatorias como il-1b y tnfa. en los procesos de sepsis y shock septico los mediadores que deben estar restringidos al sitio de infecci\u00f3n, se encuentran a nivel sist\u00e9mico, con los alteraciones funcionales que esto implica. En estos pacientes se ha encontrado un estado de tolerancia a lps, caracterizado por la incapacidad de los monocitos de elaborar una respuesta adecuada ante un est\u00edmulo con lps.  en este trabajo se estudia mediante citometr\u00eda de flujo un modelo de inducci\u00f3n de tolerancia in vitro en el que se observa una disminucion en la producci\u00f3n de tnfa que no se acompa\u00f1a de descenso de il-1b. Mediante el marcaje simult\u00e1neo de cd14 y citoquinas intracelulares comprobamos que los monocitos en los que se ha inducido tolerancia no presentan una menor expresion de cd14. Asimismo, mediante la adicci\u00f3n de agentes bloqueantes del aparato de golgi para evitar la liberaci\u00f3n de los mediadores inmunosupresores posiblemente implicados, y junto con los datos presentados de tolerancia selectiva, descartamos la implicaci\u00f3n, unicamente, de mediadores solubles.  el uso de agentes bloqueantes del aparato de golgi nos permiti\u00f3 regular negativamente la expresi\u00f3n de cd14 de membrana de los monocitos, posibilitando el estudio de la via del cd14 soluble. Comprobamos la funcionalidad de dicha via en monocitos que unen complejos scd14-lps mediante la produccion de citoquinas proinflamatorias y la imposibilidad de desarrollar tolerancia a traves de este receptor soluble en el modelo estudiado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos responsables del fenomeno de la tolerancia al lipolisacarido de escherichia coli en monocitos humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos responsables del fenomeno de la tolerancia al lipolisacarido de escherichia coli en monocitos humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vazquez Araujo M. Bego\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Sanchez Ibarrola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>ignacio Alberola gomez-escolar (vocal)<\/li>\n<li>ram\u00f3n Luis D\u00edaz Garc\u00eda (vocal)<\/li>\n<li> Garcia masdeval M\u00aa dolores (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vazquez Araujo M. Bego\u00f1a La respuesta monocitaria a un estimulo con lipopolisac\u00e1rido (lps) es la producci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1737,139,278,17749],"tags":[13420,186844,18055,14431,10691,186843],"class_list":["post-89902","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-medicina-interna","category-microbiologia","category-navarra","tag-alfonso-sanchez-ibarrola","tag-garcia-masdeval-ma-dolores","tag-ignacio-alberola-gomez-escolar","tag-melchor-alvarez-de-mon-soto","tag-ramon-luis-diaz-garcia","tag-vazquez-araujo-m-begona"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=89902"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/89902\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=89902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=89902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=89902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}