{"id":90030,"date":"2001-07-05T00:00:00","date_gmt":"2001-07-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-mama-hereditario-familiar-y-esporadico-perfil-genetico-clinico-histologico-e-inmunohistoquimico\/"},"modified":"2001-07-05T00:00:00","modified_gmt":"2001-07-05T00:00:00","slug":"cancer-de-mama-hereditario-familiar-y-esporadico-perfil-genetico-clinico-histologico-e-inmunohistoquimico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cancer-de-mama-hereditario-familiar-y-esporadico-perfil-genetico-clinico-histologico-e-inmunohistoquimico\/","title":{"rendered":"Cancer de mama hereditario, familiar y esporadico. perfil genetico, clinico, histologico e inmunohistoquimico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Emilia Cortizo Torres <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivos: se parte de la base de que existe un peque\u00f1o porcentaje de enfermas con un cancer de mama (cm) menos necesitado de la influencia de factores ambientales para su desarrollo, en las cuales existe un mayor transfondo hereditario (cmh). Los objetivos planteados fueron: medir la frecuencia del cm hereditario, cm familiar (cmf) y cm esporadico(cme). conocer su perfil genetico, clinico, histologico e inmunohistoquimico. buscar los criterios que mejor definen el cm en el momento del diagnostico de forma que se ajuste a los rasgos clinicos y \/o biologicos del cmh. Hipotesis: formulamos como hipotesis nula que no existen diferencias en el perfil clinico, genetico, histol\u00f3gico e inmunohistoquimico en el cmh, cmf y cme. la hipotesis alternativa es que el componente genetico condiciona la forma de presentaci\u00f3n clinica, el fenotipo tumoral y el comportamiento biologico del cm.  material y metodos: el trabajo de investigaci\u00f3n consisti\u00f3 en un estudio observacional de car\u00e1cter prospectivo y de tipo transversal, en el que se estudiaron a 150 enfermas de cm (hospital xeral de vigo) y a sus familias, con un seguimiento medios de 12 a\u00f1os, con un tiempo minimo de 11 a\u00f1os y un m\u00e1ximo de 14 a\u00f1os. La recogida de datos(variables clinicas, geneticas, histologicas e inmunohistoquimicas) se obtuvo de entrevistas personales y revisiones periodicas de las historias clinicas y del material de archivo del servicio de anatomia patologica de todas las enfermas y sus familias.  resultados y conclusiones: la frecuencia del cmh fue del 5% en el momento del diagn\u00f3stico, 6% a los 5 a\u00f1os y del 8% al final del seguimiento. Los cmh se caracterizan por una edad media (47,5 a\u00f1os) significativamente inferior a la de los cm no hereditarios (cmnh) (56,6 a\u00f1os), mayor frecuencia de bilateralidad (41,7% frente al 6,6% de los cmnh). La mayoria (90%) de los cmh corresponden a carcinomas grado iii, con intenso pleomorfismo nuclear (90%) un indice de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cancer de mama hereditario, familiar y esporadico. perfil genetico, clinico, histologico e inmunohistoquimico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cancer de mama hereditario, familiar y esporadico. perfil genetico, clinico, histologico e inmunohistoquimico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Emilia Cortizo Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Aguilar Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Puente dom\u00ednguez Jos\u00e9 Luis <\/li>\n<li>avelino Senra varela (vocal)<\/li>\n<li>Carlos Carlos schmitt (vocal)<\/li>\n<li>Mar\u00eda Gra\u00f1a barcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Emilia Cortizo Torres Introducci\u00f3n y objetivos: se parte de la base de que existe un peque\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,135,347,977],"tags":[1732,187038,21355,187037,62836,17778],"class_list":["post-90030","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","category-oncologia-clinica","category-santiago-de-compostela","tag-avelino-senra-varela","tag-carlos-carlos-schmitt","tag-jaime-aguilar-fernandez","tag-m-emilia-cortizo-torres","tag-maria-grana-barcia","tag-puente-dominguez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90030"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90030\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}