{"id":90037,"date":"2001-07-05T00:00:00","date_gmt":"2001-07-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-dano-genomico-en-el-cancer-colorrectal\/"},"modified":"2001-07-05T00:00:00","modified_gmt":"2001-07-05T00:00:00","slug":"papel-del-dano-genomico-en-el-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/papel-del-dano-genomico-en-el-cancer-colorrectal\/","title":{"rendered":"Papel del da\u00f1o gen\u00f3mico en el c\u00e1ncer colorrectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Risques Fern\u00e1ndez Rosa Ana <\/strong><\/h2>\n<p>La inestabilidad gen\u00f3mica presente en el tumor determina su evoluci\u00f3n. esta evoluci\u00f3n puede ocurrir por diferentes v\u00edas de progresi\u00f3n tumoral que comportan unas caracter\u00edsticas molecuares, cromos\u00f3micas y cl\u00ednico-patol\u00f3gicas concretas. El estudio del da\u00f1o gen\u00f3mico, consecuencia de la inestabilidad gen\u00f3mica, puede ayudar a caracterizar las v\u00edas de progresi\u00f3n tumoral y puede permitir la identificaci\u00f3n de los grupos de tumores con peor pron\u00f3stico.  con el objetivo de caracterizar las distintas formas de da\u00f1o gen\u00f3mico presentes en el c\u00e1ncer colorectal y de determinar su relaci\u00f3n con el comportamiento biol\u00f3gico del tumor se procedi\u00f3 a analizar el da\u00f1o gen\u00f3mico de 131 tumores colorectales espor\u00e1dicos mediante dos t\u00e9cnicas distintas: la citometr\u00eda de flujo para medir aneuploid\u00eda, yla ap-pcr para cuantificar ganancias y p\u00e9rdidas al\u00e9lica. A continuaci\u00f3n se realiz\u00f3 la comparaci\u00f3n de los  dos tipos de da\u00f1o gen\u00f3mico entre ellos y con las variables cl\u00ednico-patol\u00f3gicas y moleculares de los tumores y se determin\u00f3 el valor pron\u00f3stico de las medidas de da\u00f1o gen\u00f3mico. Tambi\u00e9n se analiz\u00f3 el papel de la aneuploid\u00eda en la diseminaci\u00f3n metast\u00e1sica.  con la intenci\u00f3n de mejorar la cuantificci\u00f3n de la aneuploid\u00eda de los tumores decidimos crear un nuevo \u00edndice (aneuploidy index, al) que tuviera en cuenta el grado y la extensi\u00f3n de la aneuploid\u00eda en el tumor. El al tiene valor pron\u00f3stico independiente del estadi\u00f3 de dukes y pemrite identificar un subgrupo de pacientes con tumores en estadi\u00f3s tempranos, pero con alto riesgo de muerte .Por otra parte, el da\u00f1o gen\u00f3mico medido por ap-pcr (gdf) cuantifica desequilibrios al\u00e9licos y tambien presenta valor pr\u00f3nostico independiete. El alto gdf se asocia a mutaciones en p53, lo que indica que la inactivaci\u00f3n de este gen podr\u00eda ser una de las causas de producci\u00f3n de desequilibrios al\u00e9licos. Adem\u00e1s, el gdf y el al son independientes y por este motivo la combinaci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del da\u00f1o gen\u00f3mico en el c\u00e1ncer colorrectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del da\u00f1o gen\u00f3mico en el c\u00e1ncer colorrectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Risques Fern\u00e1ndez Rosa Ana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Peinado Morales<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  rosa Caball\u00edn fern\u00e1ndez <\/li>\n<li>v\u00edctor ra\u00fal Moreno aguado (vocal)<\/li>\n<li>elias Campo g\u00ed\u00bcerri (vocal)<\/li>\n<li>josep ramon Germ?  lluch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Risques Fern\u00e1ndez Rosa Ana La inestabilidad gen\u00f3mica presente en el tumor determina su evoluci\u00f3n. esta evoluci\u00f3n puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,160,115,35,2820,17],"tags":[71898,71082,19732,33987,187047,38514],"class_list":["post-90037","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-genetica-humana","category-quimica","tag-elias-campo-gierri","tag-josep-ramon-germ-lluch","tag-maria-rosa-caballin-fernandez","tag-miguel-angel-peinado-morales","tag-risques-fernandez-rosa-ana","tag-victor-raul-moreno-aguado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90037"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90037\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}