{"id":90061,"date":"2001-08-05T00:00:00","date_gmt":"2001-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-la-monitorizacion-de-betalactamicos-en-situaciones-clinicas-especiales\/"},"modified":"2001-08-05T00:00:00","modified_gmt":"2001-08-05T00:00:00","slug":"utilidad-de-la-monitorizacion-de-betalactamicos-en-situaciones-clinicas-especiales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-de-la-monitorizacion-de-betalactamicos-en-situaciones-clinicas-especiales\/","title":{"rendered":"Utilidad de la monitorizacion de betalactamicos en situaciones clinicas especiales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Simon Vazquez <\/strong><\/h2>\n<p>A lo largo de este trabajo se ha estudiado la farmacocin\u00e9tica de tres betalact\u00e1micos: piperacilina, ceftriaxona y ceftazidima, en pacientes que presentan una situaci\u00f3n clinica \u00abespecial\u00bb, en la que sus caracteristicas fisiopatologicas hacian presuponer una variaci\u00f3n de la farmacocin\u00e9tica de dichos antibi\u00f3ticos. la hipotesis de trabajo fue \u00c2\u00bfpuede ser \u00fatil la monitorizaci\u00f3n de las concentraciones plasm\u00e1ticas de betalact\u00e1micos en pacientes que presentan situaciones clinicas especiales? Para ello se estudio la farmacocin\u00e9tica de estos betalact\u00e1micos en 60 pacientes. Se describe la farmacocin\u00e9tica de estos antibi\u00f3ticos en situaciones clinicas especiales (pacientes con infecciones graves, pacientes sometidos a t\u00e9cnicas continuas de depuraci\u00f3n extracorp\u00f3reas, pacientes trasplantados y pacientes cr\u00edticos ingresados en unidades de cuidados intensivos) observ\u00e1ndose que es diferente a la de los pacientes que act\u00faan como controles y a la de los pacientes descritos en la literatura. Posteriormente se ha determinado mediante t\u00e9cnicas estadisticas multiariantes que factores se asocian a la variaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos observ\u00e1ndose que para la mayoria de los par\u00e1metros farmacocin\u00e9ticos la edad, la funci\u00f3n renal y situaci\u00f3n cl\u00ednica anormal son factores que influyen en la modificaci\u00f3n de los parametros farmacocin\u00e9ticos la edad, la funci\u00f3n renal y la situaci\u00f3n clinica anormal son factores que influyen en la modificaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos. Finalmente se ha valorado la posolog\u00eda considerando los par\u00e1metros farmacocin\u00e9ticos y se vio que el 16,6% de los pacientes estaban recibieron dosis presumiblemente terap\u00e9uticas frente a un 35% que estaban recibiendo dosis infraterapeuticas y el 48,3% que recibian dosis supraterap\u00e9uticas.  la utilizaci\u00f3n de dosis supraterap\u00e9uticas en pacientes con situaciones clinicas especiales y la gran variabilidad interindividual en estos pacientes llev\u00f3 a acept<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de la monitorizacion de betalactamicos en situaciones clinicas especiales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de la monitorizacion de betalactamicos en situaciones clinicas especiales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Simon Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Azanza Perea Jos\u00e9 Ramon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Del rio zambrano joaquin <\/li>\n<li>alfonso Moreno gonzalez (vocal)<\/li>\n<li>Jes\u00fas Honorato perez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Simon Vazquez A lo largo de este trabajo se ha estudiado la farmacocin\u00e9tica de tres betalact\u00e1micos: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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