{"id":90089,"date":"2001-10-05T00:00:00","date_gmt":"2001-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteracion-de-la-colanemia-en-pacientes-con-insuficiencia-renal-cronica\/"},"modified":"2001-10-05T00:00:00","modified_gmt":"2001-10-05T00:00:00","slug":"alteracion-de-la-colanemia-en-pacientes-con-insuficiencia-renal-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteracion-de-la-colanemia-en-pacientes-con-insuficiencia-renal-cronica\/","title":{"rendered":"Alteraci\u00f3n de la colanemia en pacientes con insuficiencia renal cr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Felipe Alfonso Jimenez Vicente <\/strong><\/h2>\n<p>Objetivos  determinar si, en ausencia de enfermedad hep\u00e1tica, las alteraciones de la funci\u00f3n renal de los pacientes con insuficiencia renal cr\u00f3nica (irc), pueden repercutir sobre la composici\u00f3n cuantitativa y cualitativa del \u00abpool\u00bb de los \u00e1cidos biliares (abs). Dilucidar si existe una relaci\u00f3n entre la magnitud de estos cambios y la severidad de la insuficiencia y si los cambios revierten en pacietnes a los que se somete a trasplante renal. Investigar si el prurito, un s\u00edntoma muy frecuente en pacientes con irc, se relaciona con la hipercolanemia global o con el aumento de alguna de las especies moleculares de abs.  m\u00e9todos  el an\u00e1lisis de abs en suero se realiz\u00f3 por cromatograf\u00eda de gases asociada a espectrometr\u00eda de masas, en cuatro grupos de pacientes: control, dieta, di\u00e1lisis y trasplante.  resultados  la colanemia global fue superior en los tres grupos, dieta (10,53 +- 2,30 um), di\u00e1lesis (6,67 +- 0,65 um), trasplante (11,22 +- 1,64 um) con respecto al grupo control (5,30 +-0,50 um). El 22%, 14% y 38%, respectivamente, de los pacientes de estos grupos presentaban una colanemia &gt; 10 um, nivel que no se alcanz\u00f3 en los individuos control. En cuanto a la contribuci\u00f3n relativa de las distintas especies de abs se observ\u00f3 un marcado incremento del porcentaje de \u00e1cido quenodesoxic\u00f3lico y desoxic\u00f3lico, a costa de una menor proporci\u00f3n de \u00e1cido c\u00f3lico, en el suero de los pacientes con irc. estos cambios fueron m\u00e1s intensos en el grupo di\u00e1lisis y revert\u00edan al patr\u00f3n de la normalidad tras el trasplante renal.  conclusiones  en ausencia de enfermedad hep\u00e1tica, la irc se acompa\u00f1a de profundos cambios cuantitativos y cualitativos en el patr\u00f3n s\u00e9rico de abs, que son m\u00e1s pronunciados cuanto mayor es la severidad de la afectaci\u00f3n renal, y que revierten en gran medida cuando se recupera la funci\u00f3n renal mediante el trasplante, a pesar de que se mantiene la hipercolanemia, probablemente debida en este caso al<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraci\u00f3n de la colanemia en pacientes con insuficiencia renal cr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraci\u00f3n de la colanemia en pacientes con insuficiencia renal cr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Felipe Alfonso Jimenez Vicente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gonz\u00e1lez de buitrago Jos\u00e9 manuel <\/li>\n<li>aniceto Martin castro (vocal)<\/li>\n<li>agustin Caro paton gomez (vocal)<\/li>\n<li> Olcoz go\u00f1i Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Felipe Alfonso Jimenez Vicente Objetivos determinar si, en ausencia de enfermedad hep\u00e1tica, las alteraciones de la funci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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