{"id":90105,"date":"2001-11-05T00:00:00","date_gmt":"2001-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunohistoquimico-de-virus-y-oncogenes-aportacion-a-la-historia-de-la-cancerogenesis-del-cervix-uterino\/"},"modified":"2001-11-05T00:00:00","modified_gmt":"2001-11-05T00:00:00","slug":"estudio-inmunohistoquimico-de-virus-y-oncogenes-aportacion-a-la-historia-de-la-cancerogenesis-del-cervix-uterino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-inmunohistoquimico-de-virus-y-oncogenes-aportacion-a-la-historia-de-la-cancerogenesis-del-cervix-uterino\/","title":{"rendered":"Estudio inmunohistoquimico de virus y oncogenes. aportaci\u00f3n a la historia de la cancerog\u00e9nesis del c\u00e9rvix uterino."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Moreno-cid Garac\u00eda-suelto <\/strong><\/h2>\n<p>Se realizan seis t\u00e9cnicas inmunohistoqu\u00edmicas \/hpv, p53, c-erbb-2, catepsina d, pcna, y bcl-2) en 113 bipsias de c\u00e9rvix constituidas por 25 muestras de cin3, 27 cin2,31 cin3 y 30 de c\u00e9rvix sin patolog\u00eda.  se pretende estudiar la expresi\u00f3n y la evoluci\u00f3n de estos maracadores a lo largo del proceso de cancerog\u00e9nesis en el c\u00e9rvix.  valoramos tambi\u00e9n la intensidad y la localizaci\u00f3n en el espesor del epitelio de los casos positivos as\u00ed como la relaci\u00f3n de los maracadores entre s\u00ed.  encontramos una expresi\u00f3n precoz del bcl-2 y pcna (marcadores de proliferaci\u00f3n) enlos cin1, con una disminuci\u00f3n del primero y un aumento del segundo a lo largo del proceso.  el c-erbb-2 aparece significativamente en las displasias moderadas, lo que puede dar un significado biol\u00f3gico a la clasificaci\u00f3n de bethesda, y la cd en las graves indicando una adquisici\u00f3n precoz del fenotipo metast\u00e1sico en el c\u00e9rvix.  tambi\u00e9n encontramos una regulaci\u00f3n inversa dela cd por el c-erbb-2 y una potenciaci\u00f3n de la actividad prolfierativa con la coexpresi\u00f3n del pcna y el bcl-2.  no pudimos evidenciar que la alteraci\u00f3n del p53 sea un mecanismo fundamental de la evoluci\u00f3n de las displasias en el c\u00e9rvix.  la t\u00e9cnica inmonohistoqu\u00edmica para el hpv presenta muy escasa utilidad debido a su baja sensibilidad y especificidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunohistoquimico de virus y oncogenes. aportaci\u00f3n a la historia de la cancerog\u00e9nesis del c\u00e9rvix uterino.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunohistoquimico de virus y oncogenes. aportaci\u00f3n a la historia de la cancerog\u00e9nesis del c\u00e9rvix uterino. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Moreno-cid Garac\u00eda-suelto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Tomas Segura Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Wavarmete l\u00f3pez-c\u00f3zan <\/li>\n<li>Fernando Hern\u00e1ndez torres (vocal)<\/li>\n<li>Jos\u00e9 An\u00f3inos cachaza (vocal)<\/li>\n<li>Rafael Cano mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Moreno-cid Garac\u00eda-suelto Se realizan seis t\u00e9cnicas inmunohistoqu\u00edmicas \/hpv, p53, c-erbb-2, catepsina d, pcna, y bcl-2) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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