{"id":90133,"date":"2001-11-05T00:00:00","date_gmt":"2001-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-la-densidad-microvascular-intratumoral-en-215-casos-de-carcinoma-ductal-infiltrante-y-correlacion-con-factores-cla%c2%adnicos-y-patologicos\/"},"modified":"2001-11-05T00:00:00","modified_gmt":"2001-11-05T00:00:00","slug":"determinacion-de-la-densidad-microvascular-intratumoral-en-215-casos-de-carcinoma-ductal-infiltrante-y-correlacion-con-factores-cla%c2%adnicos-y-patologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-de-la-densidad-microvascular-intratumoral-en-215-casos-de-carcinoma-ductal-infiltrante-y-correlacion-con-factores-cla%c2%adnicos-y-patologicos\/","title":{"rendered":"Determinaci\u00f3n de la densidad microvascular intratumoral en 215 casos de carcinoma ductal infiltrante y correlaci\u00f3n con factores cl\u00ednicos y patol\u00f3gicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Bautista Laforga Canales <\/strong><\/h2>\n<p>La angiog\u00e9nesis tumoral es un complejo mecanismo consistente en una serie de eventos de m\u00faltiples pasos que incluyen la secreci\u00f3n o activaci\u00f3n de factores angiog\u00e9ncios por parte de las c\u00e9lulas tumorales, la activaci\u00f3n de enzimas proteol\u00edticas, y la proliferaci\u00f3n, migraci\u00f3n y diferenciaci\u00f3n de las c\u00e9lulas endoteliales.  la densidad microvascular dmv parece ser un indicador representativo de la actividad angiog\u00e9ncia. La dmv no s\u00f3lo es relevante para llevar el aporte de oxigeno y nutrientes a las c\u00e9lulas tumorales proliferentes, sino tambi\u00e9n est\u00e1 relacionada con la capacidad de invasi\u00f3n y de met\u00e1stasis. de esa forma, se ha sugerido que la dmv puede ser de utilidad como indicador pron\u00f3stico y como predictor de la capacidad metastatizante de las neoplasias. la determinaci\u00f3n de microvasos mediante la inmunomarcaci\u00f3n con anticuerpos espec\u00edficos y su valoraci\u00f3n semicuantitastiva son, hasta el momento, los m\u00e9todos utilizados por la mayor\u00eda de los investigadores que han estudiado la angiog\u00e9nesis en el c\u00e1ncer de mama. La valoraci\u00f3n de la dmv se ha expresado en vasos por campo, utiliz\u00e1ndose seg\u00fan los trabajos, campos de 200,250 \u00f3 400 aumentos. La mayor\u00eda de los autores indican el tama\u00f1o real de los campos, por lo que puede obtenerse la dmv por mm2, permitiendo as\u00ed comparar los resultados. En un intento de alcanzar un m\u00e9todo m\u00e1s certero para el contaje de microvasos, determinamos el n\u00famero de microvasos por 1000 c\u00e9lulas tumorales (indice angiog\u00e9ncio). Este m\u00e9todo in\u00e9dito, minimiza las posibles variaciones derivadas del ancho de los campos microsc\u00f3picos, la relaci\u00f3n estroma\/epitelio y el tama\u00f1o celular.  el presente estudio compara el n\u00famero de vasos determinado con el m\u00e9todo tradicional (vasos\/mm2) y el \u00edndice de angig\u00e9nesis en una serie de 215 casos de carcinoma ductal infiltrante nos de mama. Tambi\u00e9n estudiamos el grado de correlaci\u00f3n entre ambos m\u00e9todos y con variables clinico-patol\u00f3gicas (edad,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de la densidad microvascular intratumoral en 215 casos de carcinoma ductal infiltrante y correlaci\u00f3n con factores cl\u00ednicos y patol\u00f3gicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de la densidad microvascular intratumoral en 215 casos de carcinoma ductal infiltrante y correlaci\u00f3n con factores cl\u00ednicos y patol\u00f3gicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Bautista Laforga Canales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Ignacio Aranda L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bernat Soriz escoms <\/li>\n<li>encarnaci\u00f3n Andrada (vocal)<\/li>\n<li>ignacio L\u00f3pez fern\u00e1ndez (vocal)<\/li>\n<li>enrique Lerma (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Bautista Laforga Canales La angiog\u00e9nesis tumoral es un complejo mecanismo consistente en una serie de eventos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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