{"id":90185,"date":"2018-03-10T00:15:33","date_gmt":"2018-03-10T00:15:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/respuesta-inmune-celular-en-la-mucosa-digestiva-en-la-peste-porcina-clasica\/"},"modified":"2018-03-10T00:15:33","modified_gmt":"2018-03-10T00:15:33","slug":"respuesta-inmune-celular-en-la-mucosa-digestiva-en-la-peste-porcina-clasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/respuesta-inmune-celular-en-la-mucosa-digestiva-en-la-peste-porcina-clasica\/","title":{"rendered":"Respuesta inmune celular en la mucosa digestiva en la peste porcina clasica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Romanini <\/strong><\/h2>\n<p>Como material de estudio se utilizaron 44 cerdos large white x landrace, de ambos sexos y de 4 meses de edad, clinicamente sanos. 40 animales se inocularon, via intramuscular y con  una dosis de 10 5 tcid 50, con la cepa alfort del virus de la ppc, catalogada como virulenta. Los animales inoculados fueron sacrificados entre los 2 y 23 dpi. A todos ellos se les hizo un seguimiento clinico y antes de la eutanasia se procedio a la extraccion de sangre para la realizacion del recuento y formula leucocitaria y deteccion de citoquinas en suero. En la necropsia se observaron las diferentes lesiones macroscopicas y se tomaron muestras que los organos objeto de este trabajo. las muestras de tonsila e intestino fueron sometidas a un estudio estructural, de tunel, inmunohistoquimico (antigeno virico, celulas inmunocompetentes y citoquinas-il 1a, il 1b, il2, il4, il6, tnf-a y ultraestructural.  los hallazgos histopatologicos revelaron signos de deplecion linfoide en los foliculos linfoides a partir del 2 dpi en la tonsila y del 3 depi en el intestino, observandose tambien en esos momentos signos de muerte celular como picnosis y cariorexis, que fueron identificados como apoptosis mediante la tecnica de tunel. Fue notable la presencia de infiltrado celular en la lamina propia de ambos organos entre los 7 y 9 dpi, asi como la presencia de trastornos circulatorios hiperemia, edema y microhemorragias, principalmente en intestino a partir del 9 dpi hata el 15 dpi. En el intestino se observaron importantes dilataciones de las criptas intestinales y zonas con ulceras epiteliales desde los 11 dpi.  en cuanto a la presencia del antigeno virico, las poblaciones celulares que manifestaron en primer lugar la infeccion fueron los macrofagos presentes en las areas interfoliculares de la tonsila (2 dpi) y del intestino (5 dpi). En dias posteriores la presencia del antigeno virico se constato en linfocitos, celulas epiteliales, fibroblastos y celulas endoteliales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Respuesta inmune celular en la mucosa digestiva en la peste porcina clasica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Respuesta inmune celular en la mucosa digestiva en la peste porcina clasica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Romanini <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Gomez Villamandos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Sierra plana <\/li>\n<li>Francisco Fernandez guisado (vocal)<\/li>\n<li>Antonio Gasquez ortiz (vocal)<\/li>\n<li> Garrido jimenez M\u00aa del rosario fatima (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Romanini Como material de estudio se utilizaron 44 cerdos large white x landrace, de ambos sexos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,973,20868,495,2014,1946,3030],"tags":[175369,187271,187272,40655,19519,187270],"class_list":["post-90185","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-cordoba","category-inmunologia-veterinaria","category-patologia-veterinaria","category-porcinos","category-produccion-animal","category-virologia-veterinaria","tag-antonio-gasquez-ortiz","tag-francisco-fernandez-guisado","tag-garrido-jimenez-ma-del-rosario-fatima","tag-jose-carlos-gomez-villamandos","tag-miguel-angel-sierra-plana","tag-silvia-romanini"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90185"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90185\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}