{"id":90236,"date":"2018-03-10T00:15:37","date_gmt":"2018-03-10T00:15:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/linfomas-ta%c2%admicos-murinos-inducidos-con-radiaciones-gamma-caracterizacion-morfologica-ihq-ultraestructural-y-genetica\/"},"modified":"2018-03-10T00:15:37","modified_gmt":"2018-03-10T00:15:37","slug":"linfomas-ta%c2%admicos-murinos-inducidos-con-radiaciones-gamma-caracterizacion-morfologica-ihq-ultraestructural-y-genetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/linfomas-ta%c2%admicos-murinos-inducidos-con-radiaciones-gamma-caracterizacion-morfologica-ihq-ultraestructural-y-genetica\/","title":{"rendered":"Linfomas t\u00edmicos murinos inducidos con radiaciones gamma: caracterizaci\u00f3n morfol\u00f3gica, ihq, ultraestructural y gen\u00e9tica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Ca\u00f1amero Vaquero <\/strong><\/h2>\n<p>El tema de estudio se refiere a la correlaci\u00f3n morfo-patol\u00f3gica y gen\u00e9tica del linfoma linfobl\u00e1stico en un modelo experimental murino (h\u00edbridos entre las cepas sensibles c57bl\/6 x balb\/c tras un tratamiento carcin\u00f3geno con radiaci\u00f3n gamma. Se establecen los criterios de diagn\u00f3stico macrosc\u00f3pico, microsc\u00f3pico \u00f3ptico con t\u00e9cnicas habituales, electr\u00f3nico e inmunohistoqu\u00edmico. se estudia la implicaci\u00f3n de los genes pten, p73,p16 y cd95\/fas. Se realizan sacrificios secuenciales para valorar posibles cambios en el tiempo. De forma paralela se eval\u00faan las alteraciones gen\u00e9ticas de una muestra en fase avanzada tumoral.  se concluye que las radiaciones gamma inducen linfomas t\u00edmicos de alto grado murinos tras una dosis y en un tiempo de latencia determinados y no parecen tener distribuci\u00f3n preferente seg\u00fan la edad y el sexo. Corresponden a linfomas linfobl\u00e1sticos t con rasgos \u00f3pticos, ultraestructurales e inmunohistoqu\u00edmicos semejantes a los hom\u00f3logos humanos; ni la macroscop\u00eda ni el peso de los timos afectos son diagn\u00f3sticos en los casos tempranos de tumor y el estadiaje utilizando en linformas humanos parece m\u00e1s adecuado para indicaci\u00f3n de la agresividad-pron\u00f3stico tumoral. Los genes pten, p73 y cd95\/fas se encuentran alterados en la mayor parte de los tumores y la p\u00e9rdida de expresi\u00f3n de pten y p73 se produce en fases iniciales del tiempo de latencia tras la irradiaci\u00f3n gamma, siendo eventos precoces y mantenidos; la inactivaci\u00f3n de cd95\/fas y la sobre-expresi\u00f3n de c-myc constituyen eventos tard\u00edos que aparecen en fases avanzadas del desarrollo tumoral. Las diferentes alteraciones descritas en los timos no tumorales reflejan el mecanismo de reacci\u00f3n morfol\u00f3gico, paralelo a las alteraciones gen\u00e9ticas, pero es inespec\u00edfico; las radiaciones gamma producen adem\u00e1s lesiones con especial repercusi\u00f3n en el sistema linfoide, con hipoplasia medular y da\u00f1o secundario de los precursores t\u00edmicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Linfomas t\u00edmicos murinos inducidos con radiaciones gamma: caracterizaci\u00f3n morfol\u00f3gica, ihq, ultraestructural y gen\u00e9tica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Linfomas t\u00edmicos murinos inducidos con radiaciones gamma: caracterizaci\u00f3n morfol\u00f3gica, ihq, ultraestructural y gen\u00e9tica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Ca\u00f1amero Vaquero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Rivas Manga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ben\u00edtez ortiz <\/li>\n<li>mercedes Patron romero (vocal)<\/li>\n<li>\u00c1lvaro Ribal morell (vocal)<\/li>\n<li>mercedes Bernal boos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Ca\u00f1amero Vaquero El tema de estudio se refiere a la correlaci\u00f3n morfo-patol\u00f3gica y gen\u00e9tica del linfoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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