{"id":90237,"date":"2018-03-10T00:15:37","date_gmt":"2018-03-10T00:15:37","guid":{"rendered":""},"modified":"2018-03-10T00:15:37","modified_gmt":"2018-03-10T00:15:37","slug":"estudio-del-patron-de-expresion-intrahepatico-de-la-enzima-sintasa-inducible-del-oxido-nitrico-en-las-hepatitis-cronicas-va%c2%adricas-caracterizacion-de-mecanismos-reguladores-de-su-expresion-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-patron-de-expresion-intrahepatico-de-la-enzima-sintasa-inducible-del-oxido-nitrico-en-las-hepatitis-cronicas-va%c2%adricas-caracterizacion-de-mecanismos-reguladores-de-su-expresion-genica\/","title":{"rendered":"Estudio del patron de expresi\u00f3n intrahepatico de la enzima sintasa inducible del oxido nitrico en las hepatitis cronicas v\u00edricas. caracterizaci\u00f3n de mecanismos reguladores de su expresi\u00f3n genica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Lorenzo Majano Rodr\u00edguez <\/strong><\/h2>\n<p>La hepatitis cr\u00f3nicas v\u00edricas hcv son enfermedades hep\u00e1ticas que evoluciona, en una gran proporci\u00f3n de casos, hacia el desarrollo de lesiones irreversibles como la cirrosis y el haptocarcinoma. Aunque los factores responsables de la cronificaci\u00f3n de la infecci\u00f3n y de la progresi\u00f3n del da\u00f1o hep\u00e1ticono han sido totalmente definidos, se piensa que est\u00e1n implicados tanto factores v\u00edricos como celulares.  el \u00f3xido n\u00edtrico (on) participa en el control de funciones celulares esenciales como el mantenimiento del tono vascular, la neurotransmisi\u00f3n y el control de infecciones. Sin embargo, tambi\u00e9n puede influir en el establecimiento y promoci\u00f3n de procesos inflamatorios y carcionog\u00e9nicos; en estas situaciones on es generado fundamentalmente por la sintasa inducible del \u00f3xido n\u00edtrico (onsi), capaz de generar grandes cantidades de on  durante per\u00edodos de tiempo prolongados. La modulaci\u00f3n de la expresi\u00f3n y la actividad de las distintas isoformas de la ons y en particular de la onsi est\u00e1 considerada como una estrategia con un gran potencial terap\u00e9utico.  en este trabajo se demuestra la existencia de un incremento en la expresi\u00f3n hep\u00e1tica de la onsi en biopsias de pacientes con hcv. Adem\u00e1s, en estas mismas patolog\u00edas, hemos detectado un incremento en la acumulaci\u00f3n tisular de nitrotirosina, marcador de la interacci\u00f3n de peroxinitrito con prote\u00ednas celulares, la cual estaba significativamente relacionada con la intensidad del da\u00f1o hep\u00e1tico. Adicionalmente, hemos establecido la participaci\u00f3n del virus de la hepatitis b y, m\u00e1s concretamente, de la prote\u00edna x de este virus, en la inducci\u00f3n a nivel transcripcional del gen de la onsi a trav\u00e9s de la activaci\u00f3n del factor de transcripci\u00f3n nf-kb.  la s-adenosilmetionina (adomet) ha sido utilizada eficazmente en el tratamiento de distintas patolog\u00edas hep\u00e1ticas, sin embargo los mecanismos a trav\u00e9s de los cuales act\u00faa no son totalmente conocidos. En este trabajo hemos d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del patron de expresi\u00f3n intrahepatico de la enzima sintasa inducible del oxido nitrico en las hepatitis cronicas v\u00edricas. caracterizaci\u00f3n de mecanismos reguladores de su expresi\u00f3n genica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del patron de expresi\u00f3n intrahepatico de la enzima sintasa inducible del oxido nitrico en las hepatitis cronicas v\u00edricas. caracterizaci\u00f3n de mecanismos reguladores de su expresi\u00f3n genica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Lorenzo Majano Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Moreno Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ort\u00edz de land\u00e1zuri busca <\/li>\n<li>encarnaci\u00f3n Mart\u00ednez salas (vocal)<\/li>\n<li>gerardo Clemente ricote (vocal)<\/li>\n<li>mat\u00edas Avila zoaragoza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Lorenzo Majano Rodr\u00edguez La hepatitis cr\u00f3nicas v\u00edricas hcv son enfermedades hep\u00e1ticas que evoluciona, en una gran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,36606,35,9,491,139,280,14141],"tags":[99453,14316,4670,187347,187346,13202],"class_list":["post-90237","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-ciencias-de-la-vida","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-virologia","category-virus-viscerotropicos","tag-encarnacion-Martinez-salas","tag-gerardo-clemente-ricote","tag-manuel-ortiz-de-landazuri-busca","tag-matias-avila-zoaragoza","tag-pedro-lorenzo-majano-rodriguez","tag-ricardo-moreno-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90237"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90237\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}