{"id":90244,"date":"2018-03-10T00:15:37","date_gmt":"2018-03-10T00:15:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-bloqueo-androgenico-y-de-la-vitamina-d3-sobre-sistemas-de-senales-implicados-en-el-cancer-de-prostata\/"},"modified":"2018-03-10T00:15:37","modified_gmt":"2018-03-10T00:15:37","slug":"efecto-del-bloqueo-androgenico-y-de-la-vitamina-d3-sobre-sistemas-de-senales-implicados-en-el-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-del-bloqueo-androgenico-y-de-la-vitamina-d3-sobre-sistemas-de-senales-implicados-en-el-cancer-de-prostata\/","title":{"rendered":"Efecto del bloqueo androg\u00e9nico y de la vitamina d3 sobre sistemas de se\u00f1ales implicados en el c\u00e1ncer de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leire Montalvo Zenarruzabeitia <\/strong><\/h2>\n<p>Se estudia el efecto de la flutamida, antiandr\u00f3geno no esteroideo utilizado en cl\u00ednica para tratar el c\u00e1ncer de pr\u00f3stata, sobre diferentes sistemas de transducci\u00f3n de se\u00f1ales: receptores acoplados a prote\u00ednas g (gpcr), prote\u00ednas g heterotrim\u00e9ricas, adenilato ciclasa y pkc. As\u00ed mismo se analiza el efecto dela vitamina d3 sobre la expresi\u00f3n g\u00e9nica utilizando la t\u00e9cnica de arrays.  como ejemplo de receptores de membrana acoplados a prote\u00ednas g, se analiza el sistema receptor\/efector vip (p\u00e9ptido intestinal vasoactivo). Los estudios \u00abin vivo\u00bb (ratas tratadas con flutamida) indican que la flutamida provoca una disminuci\u00f3n significativa de la capacidad del vip para estimular la prote\u00edna efectora adenilato ciclasa en membranas de pr\u00f3stata ventral de rata, como consecuencia de una disminuci\u00f3n del n\u00famero de receptores de vip y de las subunidades alfas, alfai1\/2 y alfai3\/0 de las prote\u00ednas g, no produciendo ning\u00fan efecto sobre la propia enzima adenilato ciclasa; resultados similares se obtienen en ratas castradas. La flutamida aumenta la expresi\u00f3n de cuatro isoenzimas de la pkc (alfa, beta1, * y *), tanto en pr\u00f3stata ventral de rata como en las l\u00edneas celulares de c\u00e1ncer de pr\u00f3stata humano lncap y pc3. Por el contrario, la castraci\u00f3n produce una disminuci\u00f3n de la expresi\u00f3n de estas mismas isoformas. Este efecto de la flutamina parece ser, al menos en parte, independiente del receptor de andr\u00f3genos.  otra terapia alternativa contra el c\u00e1ncer de pr\u00f3stata es el tratamiento con agentes como la vitamina d3 m\u00e1s inhibidores selectivos de la actividad enzim\u00e1tica desacetiladora de histonas (hdac) como la tricostatina a (tsa). el tratamiento de c\u00e9lulas pc3 con vitamina d3+tsa provoca un aumento en la expresi\u00f3n de algunos genes implicados en proliferaci\u00f3n y apoptosis en esta l\u00ednea celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del bloqueo androg\u00e9nico y de la vitamina d3 sobre sistemas de se\u00f1ales implicados en el c\u00e1ncer de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del bloqueo androg\u00e9nico y de la vitamina d3 sobre sistemas de se\u00f1ales implicados en el c\u00e1ncer de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leire Montalvo Zenarruzabeitia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Prieto Villap\u00fan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel S\u00e1nchez chapado <\/li>\n<li> Juarranz moratilla m. guillermina (vocal)<\/li>\n<li>j. Campbell morey (vocal)<\/li>\n<li>Manuel Rodr\u00edguez puyol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leire Montalvo Zenarruzabeitia Se estudia el efecto de la flutamida, antiandr\u00f3geno no esteroideo utilizado en cl\u00ednica para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,160,115,992,258,17,3369],"tags":[187358,17527,187357,187356,7410,23583],"class_list":["post-90244","post","type-post","status-publish","format-standard","hentry","category-alcala","category-bioquimica","category-bioquimica-molecular","category-esteroides","category-hormonas","category-quimica","category-quimioterapia","tag-j-campbell-morey","tag-juan-carlos-prieto-villapun","tag-juarranz-moratilla-m-guillermina","tag-leire-montalvo-zenarruzabeitia","tag-manuel-rodriguez-puyol","tag-manuel-sanchez-chapado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90244"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90244\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}