{"id":90258,"date":"2018-03-10T00:15:37","date_gmt":"2018-03-10T00:15:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-receptores-de-insulina-eritrocitarios-durante-el-embarzo-humano-normal\/"},"modified":"2018-03-10T00:15:37","modified_gmt":"2018-03-10T00:15:37","slug":"estudio-de-los-receptores-de-insulina-eritrocitarios-durante-el-embarzo-humano-normal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-receptores-de-insulina-eritrocitarios-durante-el-embarzo-humano-normal\/","title":{"rendered":"Estudio de los receptores de insulina eritrocitarios durante el embarzo humano normal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa M. L\u00e1zaro Gim\u00e9nez <\/strong><\/h2>\n<p>El objetivo fundamental de este trabajo consisti\u00f3 en la obtenci\u00f3n de unos valores de referencia en los que poder apoyar los criterios de normalidad que resulten \u00fatiles como t\u00e9rmino de comparaci\u00f3n de los par\u00e1metros que caracterizan al receptor de insulina del eritrocito en su uni\u00f3n con la hormona (% bo o capacidad de ligado de la insulina al receptor, ka o constante de afinidad y n o n\u00famero de receptores por c\u00e9lula), con los determinados en estados patol\u00f3gicos durante el embarzo. Referente a material y m\u00e9todos, el estudio se realiz\u00f3 en 31 mujeres embarazadas con edades comprendidas entre los 20 y los 40 a\u00f1os que fueron sometidas a 7 extracciones de sangre durante la gestaci\u00f3n, postparto inmediato y puerperio determin\u00e1ndose en cada una, par\u00e1metros relacionados con el metabolismo hidrocarbonado: glucosa, insulina, c-p\u00e9ptido, glucag\u00f3n, cortisol y testosterona y prolactina; par\u00e1metros relacionados con el receptor de insulina: creatina eritrocitaria, % bo, ka y n. Se someti\u00f3 a cada embarazada a dos sobrecargas orales de glucosa de 50g, en el primer y tercer trimestre determin\u00e1ndose al cabo de una hora: glucosa, insulina, \u00e1cidos grasos libres, creatina eritrocitaria y par\u00e1metros de receptor de insulina. En cu\u00e1nto a los resultados obtenidos y a las conclusiones, el 17-beta-estradiol, la testosterona y la prolactina aumentaron significativamente su concentraci\u00f3n de forma progresiva desde el principo hasta el final de la gestaci\u00f3n con una correlaci\u00f3n positiva entre la concentraci\u00f3n de 17-beta-estradiol y la ka (ka-rt = +0.44, semana 12 + -2 y ka-aa = +0.50, semana 32 + &#8211; 2), siendo negativa la correlaci\u00f3n con la progesterona, m\u00e1xima en la semana 28 + &#8211; 2, (ka-aa = -0.71) cuando baja %bo, y alcanza esta hormona su concentraci\u00f3n m\u00e1s elevada, es decir la progesterona disminuye la sensibilidad a la acci\u00f3n de la insulina, o sea incrementa su resistencia. Hay un aumento de %bo desde el final del primer trimestre hasta avanza<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los receptores de insulina eritrocitarios durante el embarzo humano normal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los receptores de insulina eritrocitarios durante el embarzo humano normal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa M. L\u00e1zaro Gim\u00e9nez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Juste Rullo M. Gertrudis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andres Pie jorda <\/li>\n<li>pilar Rosel soria (vocal)<\/li>\n<li>carmen Blasco comenge (vocal)<\/li>\n<li>Jos\u00e9 Rodr\u00edguez espinosa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa M. L\u00e1zaro Gim\u00e9nez El objetivo fundamental de este trabajo consisti\u00f3 en la obtenci\u00f3n de unos valores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,3761,2135,817,135,11414,13610],"tags":[1031,87035,29501,96036,187379,187378],"class_list":["post-90258","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-de-la-reproduccion","category-fisiologia-endocrina","category-fisiologia-humana","category-ginecologia","category-metabolismo-humano","category-zaragoza","tag-andres-pie-jorda","tag-carmen-blasco-comenge","tag-jose-rodriguez-espinosa","tag-juste-rullo-m-gertrudis","tag-pilar-rosel-soria","tag-rosa-m-lazaro-gimenez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90258"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90258\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}