{"id":90328,"date":"2018-03-10T00:15:46","date_gmt":"2018-03-10T00:15:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-proteolitica-del-factor-de-transcripcion-pacc\/"},"modified":"2018-03-10T00:15:46","modified_gmt":"2018-03-10T00:15:46","slug":"activacion-proteolitica-del-factor-de-transcripcion-pacc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/activacion-proteolitica-del-factor-de-transcripcion-pacc\/","title":{"rendered":"Activacion proteolitica del factor de transcripcion pacc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eliecer Diez Hernandez <\/strong><\/h2>\n<p>El factor de transcripci\u00f3n pacc regula la expresi\u00f3n gen\u00e9rica en funci\u00f3n del ph ambiental en el hongo aspergillus nidulans. Pacc se activa por procesamiento proteol\u00edtico en el entorno del residuo 253 en respuesta al ph ambiental alcalino, para cuya transducci\u00f3n es necesaria la funcionalidad de la ruta de transducci\u00f3n integrada por los genes pal. Los resultados descritos en esta tesis demuestran que el procesamiento de pacc es un proceso que requiere, al menos, dos cortes en otros tantos putos de la proteina. Cada uno de estos dos cortes es debido a una proteasa distinta: la protasa determinativa es responsable de una corte en la regi\u00f3n carboxilo terminal de pacc y la proteasa procesativa corta en torno al residuo 253 para generar la forma procesada. Los requerimientos de pacc y la proteasa procesativa corta en torno al residuo 253 para generar la forma procesada. Los requerimientos de pacc necesarios para que las dos proteadas corten son diferentes. Asi, la proteasa determinativa parece reconocer especificamente un punto de corte situado en la region 485-511 y no requiere la presencia de la region 169-234 de pacc. El corte de la proteasa determinativa est\u00e1 regulado positivamente por la se\u00f1al del ph ambiental. Proponemos que la funci\u00f3n de este primer corte seria la de eliminar de forma irreversible las interacciones entre la regi\u00f3n carboxilo terminal de pacc y otras regiones interactivas situadas corriente arriba que mantienen la conformacion cerrada de la proteina, en respuesta a la se\u00f1al pal. El corte de la proteasa procesativa, que esta conservada en s.Crevisiae, solo puede suceder si pacc est\u00e1 en la corformaci\u00f3n abierta. Sin embargo, la transici\u00f3n de la conformaci\u00f3n cerrada de pacc a la conformaci\u00f3n abierta no es suficiente para que el procesamiento suceda. el reconocimiento del punto de corte es un proceso multifactorial. Por una parte, es necesario la regi\u00f3n comprendida entre los residuos 169 y 234. Esta regi\u00f3n forma<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion proteolitica del factor de transcripcion pacc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion proteolitica del factor de transcripcion pacc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eliecer Diez Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pe\u00f1alva Soto Miguel Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>ernesto S\u00e1nchez-herrero arbide (vocal)<\/li>\n<li>Javier Paz-ares Francisco (vocal)<\/li>\n<li>Jos\u00e9 Berenguer Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eliecer Diez Hernandez El factor de transcripci\u00f3n pacc regula la expresi\u00f3n gen\u00e9rica en funci\u00f3n del ph ambiental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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