{"id":90396,"date":"2018-03-10T00:15:51","date_gmt":"2018-03-10T00:15:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-fisiopatologicas-de-la-hipertension-arterial-inducida-por-plomo\/"},"modified":"2018-03-10T00:15:51","modified_gmt":"2018-03-10T00:15:51","slug":"bases-fisiopatologicas-de-la-hipertension-arterial-inducida-por-plomo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/bases-fisiopatologicas-de-la-hipertension-arterial-inducida-por-plomo\/","title":{"rendered":"Bases fisiopatol\u00f3gicas de la hipertensi\u00f3n arterial inducida por plomo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  De San Miguel Marques  Vidas <\/strong><\/h2>\n<p>La exposici\u00f3n continuada a bajas dosis de plomo es una causa conocida de hipertensi\u00f3n arterial e insuficiencia renal. Aunque en la \u00faltima d\u00e9cada han aparecido nuevos datos sobre la acci\u00f3n del plomo en el sistema vascular, la etiolog\u00eda de la hta inducida por plomo es a\u00fan en gran medida desconocida. basado en los datos existentes en la literatura, la hip\u00f3tesis de esta tesis fue: la intoxicaci\u00f3n por plomo provoca alteraci\u00f3n de la relajaci\u00f3n dependiente e independiente de endotelio. Para ello se utiliz\u00f3 un modelo experimental animal utilizando ratas wystar ykyoto expuestas a acetato  de plomo, 5 ppm, en el agua de bebida, durante doce meses a lo largo de los cuales se estudi\u00f3 la evoluci\u00f3n de la presi\u00f3n arterial, funci\u00f3n renal, metabolismo del sodio y \u00e1cido \u00farico y plumbemia. En una segunda fase, se analizaron los distintos componentes de la relajaci\u00f3n dependiente e independiente de endotelio durante el primer mes de exposici\u00f3n.  encontramos aumento de la presi\u00f3n arterial en los animales expuestos a plomo ya desde el primer mes de intoxicaci\u00f3n, fen\u00f3meno que se acompa\u00f1\u00f3 de disminuci\u00f3n de la excreci\u00f3n renal de sodio y de \u00e1cido \u00farico sin alteraci\u00f3n de la funci\u00f3n renal ni aparici\u00f3n de proteinuria.  a los treinta d\u00edas de exposici\u00f3n, los segmentos vasculares de los animales tratados con plomo presentaron disminuci\u00f3n de la capacidad de relajaci\u00f3n frente acetilcolina, agonista de la enos, y nitroprusiato s\u00f3dico, dador ex\u00f3geno de no. Esto se acompa\u00f1\u00f3 de un aumento de la expresi\u00f3n vascular de enos y caveolinas, y disminuci\u00f3n de ambas subunidades de la guanialto ciclasa solubre vascular, as\u00ed como de la generaci\u00f3n de gmpc en los vasos de los animales expuestos.  concluimos que este modelo de intoxicaci\u00f3n con plomo refleja la forma cl\u00ednica de exposici\u00f3n medioambiental. El plomo induce alteraci\u00f3n tanto de la relajaci\u00f3n dependiente de endotelio, como de la relajaci\u00f3n independiente de endotelio, debido a di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases fisiopatol\u00f3gicas de la hipertensi\u00f3n arterial inducida por plomo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases fisiopatol\u00f3gicas de la hipertensi\u00f3n arterial inducida por plomo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  De San Miguel Marques  Vidas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Barrientos Guzm\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>Jaime Alvarez grande (vocal)<\/li>\n<li>joaquin Ortu\u00f1o mirete (vocal)<\/li>\n<li>Jos\u00e9 angel Porres benito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda De San Miguel Marques Vidas La exposici\u00f3n continuada a bajas dosis de plomo es una causa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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