{"id":90441,"date":"2001-01-06T00:00:00","date_gmt":"2001-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-mecanismos-moleculares-asociados-a-la-perdida-de-masa-muscular-en-situaciones-catabolicas-activacion-de-proteinas-desacopladoras-y-apoptosis\/"},"modified":"2001-01-06T00:00:00","modified_gmt":"2001-01-06T00:00:00","slug":"nuevos-mecanismos-moleculares-asociados-a-la-perdida-de-masa-muscular-en-situaciones-catabolicas-activacion-de-proteinas-desacopladoras-y-apoptosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevos-mecanismos-moleculares-asociados-a-la-perdida-de-masa-muscular-en-situaciones-catabolicas-activacion-de-proteinas-desacopladoras-y-apoptosis\/","title":{"rendered":"Nuevos mecanismos moleculares asociados a la perdida de masa muscular en situaciones catabolicas: activacion de proteinas desacopladoras y apoptosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Busquets Rius <\/strong><\/h2>\n<p>La p\u00e9rdida de masa muscular es una de las caracter\u00edsticas comunes que se presentan durante situaciones catab\u00f3licas como por ejemplo durante el crecimiento de un tumor, la sepsis o el ayuno. En esta tesis se ha profundizado en el estudio de la regulaci\u00f3n de la proteolisis leucina presenta un papel inhibidor de la proteolisis incrementada en situaci\u00f3n de crecimiento tumoral a nivel tanto sobre la actividad enzim\u00e1tica del sistema lisosomal como sobre la expresi\u00f3n g\u00e9nica de algunos componentes del sistema proteol\u00edtico dependiente de ubiquitina y lisosomal. Se ha demostrado tambi\u00e9n un papel contraregulador y lisosomal. Se ha demostrado tambi\u00e9n un papel contraregulador de calcio en la proteolisis incrementada durante la presencia de un tumor.  en esta tesis se ha pretendido tambi\u00e9n el estudio de la expresi\u00f3n de los nuevos miembros de la familia de las prote\u00ednas desacopladoras de la respiraci\u00f3n mitocondrial: ucp2, ucp3 y bmcp-1. Se ha demostrado que durante el crecimiento tumoral incrmenta la expresi\u00f3n g\u00e9nica de la ucp2 y ucp3 en el m\u00fasculo esquel\u00e9tico, de la ucp2 en el cerebro. Este \u00faltimo efecto se observa tambi\u00e9n en ratones a los que se ha administrado lps agudamente. los factores que estan implicados en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de dichas prote\u00ednas son las concentraciones circulantes de los \u00e1cidos grasos y la citoquina tnf-a.  por \u00faltimo se realiz\u00f3 un estudio para analizar la existencia del fen\u00f3meno de la apoptosis en el m\u00fasculo esquel\u00e9tico de animales portadores de tumor. este fen\u00f3meno tiene lugar en estos animales y est\u00e1 contribuyendo al desgaste muscular caracter\u00edctico del s\u00edndrome de la caquexia ancerosa. El tnf-a se encuentra implicado en la inducci\u00f3n a la apoptosis en el m\u00fasculo esquel\u00e9tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos mecanismos moleculares asociados a la perdida de masa muscular en situaciones catabolicas: activacion de proteinas desacopladoras y apoptosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos mecanismos moleculares asociados a la perdida de masa muscular en situaciones catabolicas: activacion de proteinas desacopladoras y apoptosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Busquets Rius <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep M\u00aa Argil\u00e9s Huguet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Marta (secretario) Llovera tomas <\/li>\n<li>francesc xavier Remesar betlloch (vocal)<\/li>\n<li>sim\u00f3 Schwartz riera (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Busquets Rius La p\u00e9rdida de masa muscular es una de las caracter\u00edsticas comunes que se presentan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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