{"id":90442,"date":"2001-01-06T00:00:00","date_gmt":"2001-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/historia-natural-de-la-hepatitis-cronica-c-y-factores-histologicos-con-valor-predictivo-de-evolucion\/"},"modified":"2001-01-06T00:00:00","modified_gmt":"2001-01-06T00:00:00","slug":"historia-natural-de-la-hepatitis-cronica-c-y-factores-histologicos-con-valor-predictivo-de-evolucion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/historia-natural-de-la-hepatitis-cronica-c-y-factores-histologicos-con-valor-predictivo-de-evolucion\/","title":{"rendered":"Historia natural de la hepatitis cronica c y factores histologicos con valor predictivo de evolucion."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Joya Vazquez Pedro Pablo <\/strong><\/h2>\n<p>La hetopat\u00eda por el virus de la hepatitis c(vhc) es una importante causa de morbilidad y mortalidad, y muchas interrogantes deben a\u00fan derveladas con respecto a su historia natural. Este estudio tuvo como objetivo evaluar su evoluci\u00f3n a largo plazo y el estudio de factores potencialmente asociados con una progresion. Se estudi\u00f3 una cohorte de 201 enfermos diagnosticados consecutivamente de hepatitis cronica nanb\/c mediante biopsia hepatica entre 1971 y 1977, que fueron seguidos hasta diciembre de 1998 o hasta su muerte. Pacientes con acentuada ingesta de alcohol fueron excluidos de este estudio. Varibles obtenidas al tiempo del diagnostico: epidemiol\u00f3gicas, clinicas, de laboratorio e histolog\u00eda fueron recogidas con el prop\u00f3sito de determinar su asociaci\u00f3n con el desarrollo de cirrosis y descompensaci\u00f3n hep\u00e1tica.  resultados.-Tomando como referencia los datos obtenidos al final del seguimiento. el desarrollo de cirrosis y descomposici\u00f3n hep\u00e1tica pudo ser evaluado en 160 pacientes. Sesenta y siete (48,5%) de los 138 pacientes en los que pudo ser evaluada, desarrollaron cirrosis. Un valor de aparato aminotransferasa (ast)&gt; a 70 iu\/l fue asociado con el desarrollo de cirrosis (odds ratio (or) 4.2, 95% ci 1.3-13.8). La descompensacion hepatica ocurrio en 32 (20%) de los 160 pacientes. Con una probabilidad acumulada de 2.8% a 10 a\u00f1os, 5.2% a 15 a\u00f1os y 19.8% a 20 a\u00f1os. El \u00fanico factor asociado independientemente con el desarrollo de descomposici\u00f3n hepatica fue la presencia de fibrosis (estadio 3) en la biopsia inicial (or 4.1,95% ic 1.22-13.9). La muerte relacionada con enfermedad hepatica ocurri\u00f3 unicamente en 24(15%)de los 160 pacientes en los que pudo ser evaluada. A diferencia de esta cohorte de pacientes diagnosticada en los 70\u00c2\u00bfs, un grupo reciente de 200 pacientes diagnosticado con hepatitis cronica c en 1999, mostro se significativamente m\u00e1s joven en el momento del diagn\u00f3stico, ser m\u00e1s frecuentemente asintom\u00e1tico,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Historia natural de la hepatitis cronica c y factores histologicos con valor predictivo de evolucion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Historia natural de la hepatitis cronica c y factores histologicos con valor predictivo de evolucion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Joya Vazquez Pedro Pablo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Bruguera Cortada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep antoni Bomb\u00ed latorre <\/li>\n<li>vila Josep llach (vocal)<\/li>\n<li>angels Gines gibert (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joya Vazquez Pedro Pablo La hetopat\u00eda por el virus de la hepatitis c(vhc) es una importante causa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,1085,491,139],"tags":[20003,14013,187678,13802,187679],"class_list":["post-90442","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-enfermedades-infecciosas","category-gastroenterologia","category-medicina-interna","tag-angels-gines-gibert","tag-josep-antoni-bombi-latorre","tag-joya-vazquez-pedro-pablo","tag-miguel-bruguera-cortada","tag-vila-josep-llach"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90442","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90442"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90442\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90442"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90442"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90442"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}