{"id":90444,"date":"2001-01-06T00:00:00","date_gmt":"2001-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-sobre-la-maduracion-fenotipica-y-funcional-de-las-celulas-plasmaticas-humanas\/"},"modified":"2001-01-06T00:00:00","modified_gmt":"2001-01-06T00:00:00","slug":"estudio-sobre-la-maduracion-fenotipica-y-funcional-de-las-celulas-plasmaticas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-sobre-la-maduracion-fenotipica-y-funcional-de-las-celulas-plasmaticas-humanas\/","title":{"rendered":"Estudio sobre la maduraci\u00f3n fenotipica y funcional de las celulas plasm\u00e1ticas humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Manuel Medina Prieto <\/strong><\/h2>\n<p>Las c\u00e9lulas plasm\u00e1ticas cp constituyen la fase de m\u00e1xima diferenciaci\u00f3n de los linfocitos b, estando espcializadas e nla s\u00edntesis a gran escala de anticuerpos ac altamente espec\u00edficos.E n los sistemas animales, las cp aparecen,tras una inmunizaci\u00f3n, en los \u00f3rganos linfoides perifericos y posteriormente en \u00f3rganos de acantonamiento como la medula osea mo. La aparici\u00f3n de cp en los territorios de localizaci\u00f3n final dependen de la serie de procesos de activaci\u00f3n antigeno-esepc\u00edficos que generan, en los \u00f3rganos linfoides perifericos, un precursor con capacidad de circular transitoriamente y alojarse en dichos territorios. En los modelos murinos existen dentro del compartimento de las cp rasgos de heterogeneidas entre las cp reci\u00e9n generadas y las que residen en los territorios de alojamiento final, en cu\u00e1nto a su capacidad de supervivencia y al grado de afinidad de los ac que producen. En humanos el proceso de generaci\u00f3n de las cp parece a grandes rasgos similar al de los modelos animales y , aunque los abordajes \u00abin vivo\u00bb est\u00e1n obviamente m\u00e1s limitados, los sistemas \u00abin vitro\u00bb sugieren diferencias entre las cp reci\u00e9n generadas (amigdala) y las de las zonas de alojamiento final mio. En el presente trabajo se estudia la heterogeneidad de las cp humanas de territorios perif\u00e9ricos (amigdala y sangra) y finales (mo y lamina propia) en cu\u00e1nto a  sensibilidad a apoptosis cuando se activa el receptor cd95 fas y a expresi\u00f3n de mol\u00e9culas relacionadas con diferenciaci\u00f3n, supervivencia y adhesi\u00f3n. la puesta a punto de protocolos de purificaci\u00f3n a permitido aislar de un modo efectivo las cp de la amigdala, la lamina propia y la mo, y describir la presencia de cp en la sangre (tras inmunizaci\u00f3n) y de una poblaci\u00f3n alternativa en la amigdala. Las cp de los territorios perifericos al contrario de las que se alojan en los territorios finales, son sensibles a la apoptosis via cd95. Desde la periferia hasta los \u00f3rganos de deposito<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio sobre la maduraci\u00f3n fenotipica y funcional de las celulas plasm\u00e1ticas humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio sobre la maduraci\u00f3n fenotipica y funcional de las celulas plasm\u00e1ticas humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Manuel Medina Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Brieva Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Ortiz de landiazuri manuel <\/li>\n<li>ernesto Rold\u00e1n Santiago (vocal)<\/li>\n<li>Manuel Antonio Rodr\u00edguez iglesias (vocal)<\/li>\n<li>Francisco Garc\u00eda cuzar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Manuel Medina Prieto Las c\u00e9lulas plasm\u00e1ticas cp constituyen la fase de m\u00e1xima diferenciaci\u00f3n de los linfocitos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506,35,32218,1737],"tags":[17597,187683,132482,7334,1851,187682],"class_list":["post-90444","post","type-post","status-publish","format-standard","hentry","category-cadiz","category-ciencias-de-la-vida","category-formacion-de-anticuerpos","category-inmunologia","tag-ernesto-roldan-santiago","tag-francisco-garcia-cuzar","tag-francisco-manuel-medina-prieto","tag-jose-antonio-brieva-romero","tag-manuel-antonio-rodriguez-iglesias","tag-ortiz-de-landiazuri-manuel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90444"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90444\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}