{"id":90448,"date":"2001-01-06T00:00:00","date_gmt":"2001-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-analogos-semirrigidos-de-calcitriol-y-correlacion-estructura-actividad-biologica\/"},"modified":"2001-01-06T00:00:00","modified_gmt":"2001-01-06T00:00:00","slug":"sintesis-de-analogos-semirrigidos-de-calcitriol-y-correlacion-estructura-actividad-biologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-analogos-semirrigidos-de-calcitriol-y-correlacion-estructura-actividad-biologica\/","title":{"rendered":"Sintesis de analogos semirrigidos de calcitriol y correlaci\u00f3n estructura-actividad biologica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Varela Busto <\/strong><\/h2>\n<p>La 1a, 25-dihidroxivitamina d3 es la forma hormonal de la vitamina d3 que regula el metabolismo del calcio y del f\u00f3sforo, interviene en los procesos de diferenciaci\u00f3n y proliferaci\u00f3n celular y participa en el funcionamiento del sistema hematopoy\u00e9tico e inmunol\u00f3gico. Se cree que la mayoria de sus acciones biol\u00f3gicas tienen lugar via un mecanismo genomico a traves de un complejo hormona-receptor. Por ello, el estudio de la relaci\u00f3n estructura-actividad biol\u00f3gica de sus an\u00e1logos permitir\u00eda, en principio, discriminar entre las distinas acciones de la vitamina d.  con este objetivo, se ha llevado a cabo la sintesis de analogos del calcitriol con estructura r\u00edgida en los carbonos c-18 y c-21 en forma de unidad ciclopent\u00e1nica y con las cadenas laterales semirr\u00edgidas en la posici\u00f3n c-20. Se prepar\u00f3 un precursor clave a partir del diol de inhoffen mediante funcionalizaci\u00f3n radicalaria de la posici\u00f3n c-18. Las cadenas laterales se introdujeron por reacciones de acoplamiento catalizadas por pd entre enol triflatos y estananos y alquinos. Para la construcci\u00f3n del sistema tri\u00e9nico se utiliz\u00f3 la ruta wittig-horner. Los resultados biol\u00f3gicos indicaron que estos an\u00e1logos presentan una baja afinidad por el receptor nuclear de la vitamina d.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de analogos semirrigidos de calcitriol y correlaci\u00f3n estructura-actividad biologica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de analogos semirrigidos de calcitriol y correlaci\u00f3n estructura-actividad biologica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Varela Busto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mouri\u00f1o Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  alberto Marco ventura <\/li>\n<li>v\u00edctor Mart\u00ednez merino (vocal)<\/li>\n<li>cosme Garcia Francisco (vocal)<\/li>\n<li> Pumar duran M\u00aa carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Varela Busto La 1a, 25-dihidroxivitamina d3 es la forma hormonal de la vitamina d3 que regula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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