{"id":90454,"date":"2001-01-06T00:00:00","date_gmt":"2001-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-en-la-neurotransmision-glutamatergica-y-gabaergica-tras-una-lesion-de-la-va%c2%ada-nigroestriada-de-distinta-severidad-efecto-modulador-de-la-met-encefalina\/"},"modified":"2001-01-06T00:00:00","modified_gmt":"2001-01-06T00:00:00","slug":"alteraciones-en-la-neurotransmision-glutamatergica-y-gabaergica-tras-una-lesion-de-la-va%c2%ada-nigroestriada-de-distinta-severidad-efecto-modulador-de-la-met-encefalina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-en-la-neurotransmision-glutamatergica-y-gabaergica-tras-una-lesion-de-la-va%c2%ada-nigroestriada-de-distinta-severidad-efecto-modulador-de-la-met-encefalina\/","title":{"rendered":"Alteraciones en la neurotransmisi\u00f3n glutamat\u00e9rgica y gaba\u00e9rgica tras una lesi\u00f3n de la v\u00edanigroestriada de distinta severidad: efecto modulador de la met-encefalina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Serrano Ruiz Alba <\/strong><\/h2>\n<p>Uno de los modelos experimentales de la enfermedad de parkinson (ep), m\u00e1s ampliamente utilizado, es la lesi\u00f3n unilateral severa con 6-ohda en rata. En \u00e9l se reproducen las alteraciones neuroqu\u00edmicas correspondientes al estad\u00edo m\u00e1s avanzado de la patolog\u00eda, pero para el estudio de la fase presintom\u00e1tica de la misma era necesario un modelo de lesi\u00f3n parcial. Es bien conocida la dificultad de obtener un modelo de tales caracter\u00edsticas y a\u00fan m\u00e1s cuando se combinan varios criterios. No obstante, en esta tesis se pudieron establecer tres grupos de lesi\u00f3n: sin efecto, moderadas y severas, atendiendo a par\u00e1metros conductuales, bioqu\u00edmicso (amin\u00e9rgicos) e histol\u00f3gicos. una vez caracterizado el modelo, se procedi\u00f3 a valorar las lateraciones esratales en la neurotransmisi\u00f3n glutamat\u00e9rgica y gaba\u00e9rgica. En las ratas con una lesi\u00f3n severa, a los 4 meses psotlesi\u00f3n, se confirm\u00f3 el aumento en la liberaci\u00f3n tanto de \u00e1cidoglut\u00e1mico (glu) como de gaba, ya descrito en estudios realizados a las tres semanas. Este hecho, tambi\u00e9n presente en los animales con una lesi\u00f3n parcial o moderada, puso de manifiesto la existencia de un umbral para los cambios en los sistemas aminoacid\u00e9rgicos y la ausencia de correlaci\u00f3n directa entre \u00e9stos y el comportamiento rotacional. otro de los objetivos de la tesis consisti\u00f3 en el estudio de la actividad de la met-encefalina (met-enk) sobre la liberaci\u00f3n estriatal de glu y gaba, en los distintos grupos de lesi\u00f3n. Los neurop\u00e9ptidos, ampliamente representados en los gangliso basales, se han revelado como potentes moduladores de la actividad de los diferentes sistemas de neurotransmisi\u00f3n, por lo que su investigacion en la ep, podr\u00eda ser muy relevante para la patolog\u00eda. La met-enk \u00abin vivo\u00bb ejerci\u00f3 un efecto inhibidor sobre la liberaci\u00f3n de ambos amino\u00e1cidos, que disminuy\u00f3 proprocionalmente a la gravedad de la lesi\u00f3n.La reducic\u00f3n de la actividad del p\u00e9ptido se corresponder\u00eda con un incremen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones en la neurotransmisi\u00f3n glutamat\u00e9rgica y gaba\u00e9rgica tras una lesi\u00f3n de la v\u00edanigroestriada de distinta severidad: efecto modulador de la met-encefalina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones en la neurotransmisi\u00f3n glutamat\u00e9rgica y gaba\u00e9rgica tras una lesi\u00f3n de la v\u00edanigroestriada de distinta severidad: efecto modulador de la met-encefalina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Serrano Ruiz Alba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> L\u00f3pez De Ceballos Lafarga Mar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Mora teruel <\/li>\n<li>rosario Mortalla villalba (vocal)<\/li>\n<li> Grandas p\u00e9rez Francisco Jos\u00e9 (vocal)<\/li>\n<li> Mena g\u00f3mez Mar\u00eda \u00e1ngeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Serrano Ruiz Alba Uno de los modelos experimentales de la enfermedad de parkinson (ep), m\u00e1s ampliamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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