{"id":90490,"date":"2008-11-12T00:00:00","date_gmt":"2008-11-12T00:00:00","guid":{"rendered":""},"modified":"2008-11-12T00:00:00","modified_gmt":"2008-11-12T00:00:00","slug":"analisis-de-los-proteomas-y-glicoproteomas-del-tegumento-y-de-los-productos-de-excrecion-secrecion-de-schistosoma-bovis-estudio-de-la-interaccion-del-parasito-con-el-sistema-fibrinola%c2%adtico-del-h","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/analisis-de-los-proteomas-y-glicoproteomas-del-tegumento-y-de-los-productos-de-excrecion-secrecion-de-schistosoma-bovis-estudio-de-la-interaccion-del-parasito-con-el-sistema-fibrinola%c2%adtico-del-h\/","title":{"rendered":"An\u00e1lisis de los proteomas y glicoproteomas del tegumento y de los productos de excreci\u00f3n-secreci\u00f3n de schistosoma bovis. estudio de la interacci\u00f3n del par\u00e1sito con el sistema fibrinol\u00edtico del hospedador"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alicia Ramajo Hern\u00e1ndez <\/strong><\/h2>\n<p>Schistosoma bovis es un trematodo par\u00e1sito que vive en el lecho vascular de los rumiantes. Este par\u00e1sito es pat\u00f3geno para los ovinos y bovinos dom\u00e9sticos y genera p\u00e9rdidas significativas en las explotaciones ganaderas. Pese a su inter\u00e9s veterinario es un par\u00e1sito pr\u00e1cticamente desconocido a nivel molecular. En consecuencia, el objetivo de esta tesis ha sido la identificaci\u00f3n de las prote\u00ednas parasitarias que intervienen en las relaciones s. Bovis-hospedador para facilitar la identificaci\u00f3n de ant\u00edgenos parasitarios de inter\u00e9s vacunal, diagn\u00f3stico o de nuevas dianas para f\u00e1rmacos.  Para ello se han analizado los proteomas, inmunomas y glicoproteomas del tegumento y de los productos de excreci\u00f3n-secreci\u00f3n de los vermes adultos de s. Bovis mediante electroforesis bidimensional y espectrometr\u00eda de masas. De este modo se han identificado las proteinas antig\u00e9nicas, las mayoritarias y las glicosiladas de cada uno de esos extractos. Tambi\u00e9n se han identificado los principales glicanos expresados por el par\u00e1sito, encontr\u00e1ndose un perfil glic\u00e1nico similar al expresado por los esquistosomas que infectan a personas, salvo en que s. Bovis expresa el ant\u00edgeno lewisy y los esquistosomas de humanos no. Por \u00faltimo se ha comprobado, mediante inmunofluorescencia y microscop\u00eda confocal, que los machos de s. Bovis fijan -y activan- sobre su superficie al plasmin\u00f3geno del hospedador evitando as\u00ed la formaci\u00f3n de co\u00e1gulos en torno a ellos, y se han identificado 10 prote\u00ednas tegumentales fijadoras de plasmin\u00f3geno.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de los proteomas y glicoproteomas del tegumento y de los productos de excreci\u00f3n-secreci\u00f3n de schistosoma bovis. estudio de la interacci\u00f3n del par\u00e1sito con el sistema fibrinol\u00edtico del hospedador<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de los proteomas y glicoproteomas del tegumento y de los productos de excreci\u00f3n-secreci\u00f3n de schistosoma bovis. estudio de la interacci\u00f3n del par\u00e1sito con el sistema fibrinol\u00edtico del hospedador <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alicia Ramajo Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Oleaga P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: M\u00aa yolanda Manga gonz\u00e1lez <\/li>\n<li>mercedes G\u00f3mez bautista (vocal)<\/li>\n<li>Antonio Marcilla d\u00edaz (vocal)<\/li>\n<li>Antonio Muro \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alicia Ramajo Hern\u00e1ndez Schistosoma bovis es un trematodo par\u00e1sito que vive en el lecho vascular de los 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